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22 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Mechanism of action for Amphotericin B
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binds to ergosterol and forms pores in membrane - broad spectrum for fungal infections
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Why is amphotericin known as amphoterrible?
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it sucks to get it. severe chills (treated with meperidine), headache, fever, hypotension, GI, tachypna
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What is the difference between amphotericin B and amphotericin B lipid formula?
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Less nephrotoxicity for lipid formula.
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How do you minimize nephrotoxicity and electrolyte loss while using amphotericin b?
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saline infusion
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Mechanism for flucystosine.
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fungal cystosine deaminase to 5-FU
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Why are flucytosine and amphotericin B used together?
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allows lower than normal doses to minimize toxicity and synergistic mechanism of action.
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Azoles require an acidic environment (except fluconazole) so you can't use with?
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PPI - can't give at same time as H2 blocker either
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Griseofulvin absorption is improved with what?
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fatty meal such as McDonalds
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"Grease"
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Ketoconazole endocrine adverse reactions.
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gynecomastia, oligospermia, irregular menses, decrease in libido
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Terbinafine causes weight loss because of this side effect.
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causes everything to taste metallic.
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-quine think problems in these places
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heart, brain, liver and blood
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Prophylaxis of malaria
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chloroquine
primaquine mefloquine |
THREE
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Treatment of malarial attacks (acute)
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chloroquine
quinine |
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anti-malarial drug that is effective against gametocytes and hepatic form.
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primaquine
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Chloroquine mechanism
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ihibition of heme processing (intracellular accumulation of heme is toxic to parasite)
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chloroquine resistant malaria (plasmodium falciparum)
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quinine
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pregnancy category of quinine
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category X
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benefit of mefloquine
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long half life - can miss a dose and is broad spectrum against many parasites
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half life
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notable side affect about Iodoquinol
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contains iodine - thyroid enlargment
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drug that gives metallic taste, disulfiram like reaction with alcohol, dark urine, and is carcinogenic
useful in bacterial and parasitic infections |
metronidazole
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Ivermectin adverse reaction
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mazzoti reaction (parasitic cell contents released into circulation)
use for nematodes (round worms) |
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praziquantal uses
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trematodes (flukes)
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