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7 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Amphotercin B
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MOA:
Binds to ergosterol(fungi sterol) forms membrane pores that allow leakage of electrolytes |
Serious Systemic InfectionS
Mucor, Cryptococcus, Blastomyces, Coccidiodes, Aspergillus, Histoplasma, Candida Intra Thecally form Menigitis (Not penetrate BBB) AE: Fever/ Chills (shakeand bake) Hypotension, Nephrotoxic arryhtmia anemia, IV phlebitis Hydration reduces nephrotox |
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NYSTATIN
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MOA:
Same as AMPHO... Topical form because to toxic systemic |
Candidiasis oral
diaper rash or vaginal candida |
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AZOLES
Fluconazole, Ketoconazole, Miconazole, clotrimazole itraconazole, voriconazole |
Systemic Mycoses
MOA: Inhibit fungal sterol (egosterol) synthesis inbiting the p 450 enzymes that congfert lanosterol to ergosterol |
Fluconazol- Cyrotococcal Meningitis in AIDS
Candida Keto- blasto Clotramazole and miconizole topical infections AE: Gynecomastia, Lver dysfn(inhibits cytochrome p450) fever chills |
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Flucytosine
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inhibits DNA synthesis by conversion -->5-FLouroURacil
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Used systemic infections (candida crypto) in comvination with ampho B
AE: NVD bone marro supression |
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CaSPOFUNGIN
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moa:
iNHIBIts cell wall synthesis by inhibiting synth of beta glucan |
Invasive aspergillosis
GI Upset Flushing |
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Terbenafine
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Inhibits Fungal enzyme Squalene epoxide
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Treat dermatophytes
onychomycosis |
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Griseofulvin
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Interferes with microtuble function disrupts mitosis
Deposits in keratin containing tissues |
Oral or superficial .. inhibits dermatophite growht
AE: Teratogenic carcinogenic, confusions, headaches ↑ P450 ↓Warfarin levels |
