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11 Cards in this Set
- Front
- Back
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Amphotericin B
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Binds ergosterol, PORES
Potentially fatal fungal infections; invasive aspergillosis, diseminated candidiasis Shake and bake, hypotension, nephrotoxicity, anemia |
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Nystatin
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Binds to ergosterol, disrupts fungal membranes
Oral candidiasis, topical for diaper rash or vaginal candidiasis |
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Azoles
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Targets 14 alpha demethylase, inhibits ergosterol synthesis, leaky membrane
GI distress, Rash, HEPATOTOXICITY, drug interactions with CYP3A4 |
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Ketoconazole
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Alternative amphotericin B for treating systemic/mucocutaneous fungal infections
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Fluconazole
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significantly longer t1/2 compared to ketoconazole, good penetration into CSF and eye
oral absoprtion with less liver metabolism ttx cryptococcal meningitis, prevention of candidal infection for transplants |
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Itraconazole
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oral absorbtion improved with food
exculsively hepatic metabolism systemic admin fewer side effects vs ketoconazole |
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Voriconazole
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80-90% bioavailable improved on empty stomach
exclusively hepatic metabolism ttx: invasive aspergillosis and candidemia |
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Allylamines
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sequalene 2,3 epoixdase
Naftifine: topical Terbinafine: both oral and topical Inhibition of ergosterol biosynthesis |
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Flucytosine
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5FC converted by cytosine deaminase to 5-FU to 5FUMP:
mRNA inhibits protein synthesis 5-FdUMP to inhibit thymidylate synthase selective toxicity: human cytosine deaminase cannot deaminate 5-FC RESISTANCE RAPIDLY DEVELOPS |
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Griseofulvin
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Interfere with microtubule assembly
Lack of active transport into the animal cell ttx: severe infections of hair nails palms soles |
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drugs that inhibit cell wall biosynthesis
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capsofungin, micafungin, anidulafungin
irreversible inhibit 1, 3 beta glucan synthase FUNGICIDAL ttx: esophageal candidiasis, candidemia, Salvage therapy for invasive aspergillosis Extremely high toxicity rates: 14% patients get fever nausea vomiting |
