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7 Cards in this Set
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- Back
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Ampho B
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MOA= Bings ergosterol in membrane to tear holes --> leaks
Uses= used in systemic mycoses (cryptococcus, aspergillus, etc) Fungal Meningitis= intrathecal (won't cross BBB) Toxic= Fever/Chills, Hypotension, Nephrotoxic, arryhthmia (Amphoterrible) |
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Azoles (ketoconazole, Fluconazole, etc)
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MOA= inhibits ergosterol synthesis
Uses= Systemic Mycoses Fluconazole= AIDS cryptococcal meningitis, Candidiasis Toxic= Inhibits p450, increases estrogen (gynocomastia), inhibits hormones, |
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Flucytosine
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MOA= converted to 5-FU --> blocks DNA synthesis
Use= sytemic canidida, Cryptococcus Toxic= Nausea, vomiting, diarrhea, bone marrow suppression |
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Nystatin
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Only used for oral mouth wash and topical cream
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Caspofungin
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MOA= inhibit cell wall synthesis
Use= Invasive Aspergillis Toxic= GI upset, flushing |
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Terbinafine
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MOA= blocks squalene epoxidase (Step in ergosterol synthesis)
Use= Topical dermatophytoses (oncychomycoses) |
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Griseofulvin
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MOA= interupts microtubule fxn, blocks mitosis, accumulates in nails
Use= Oral trt for dermatophytoses (tinea, ringworm) Toxic= Teratogen, carcinogen, confusion, increases warfarin metabolism |
