Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
What is the mechanism of action of Tricyclic antidepressants?
|
Enhance the actions of biogenic amines by inhibiting reuptake.
|
|
|
What is the prototypic Tricyclic antidepressant?
|
Imipramine (Tofranil)
|
|
|
What is the mechanism of action of Imipramine (Tofranil)?
|
Blocks norepinephrine reuptake.
|
|
|
What are the adverse effects of Tricyclic/MAO Inhibitor drug interactions?
|
Hypertensive crisis
Tachycardia Seizures Hyperpyrexia |
|
|
What are the adverse effects of Tricyclic/Antihypertensive drug interactions?
|
Orthostatic Hypotension
|
|
|
Tricyclic antidepressants result in additive effects with what other types of drugs?
|
CNS depressants
|
|
|
What are the adverse effects of Tricyclic/Sympathomimetic drug interactions?
|
Cardiotoxicity
|
|
|
What are the adverse effects of Tricyclic/Cimetidine (Tagamet) drug interactions?
|
Decreased liver metabolism (results in higher drug levels)
|
|
|
What are the most common adverse effects of Tricyclic antidepressants?
|
Urinary retention
Constipation Weight gain Sexual dysfunction Confusion/Delirium Orthostatic Hypotension |
|
|
What are some examples of MAO inhibitors?
|
Phenelzine (Nardil)
Tranylcypromine (Parnate) Clorgyline Isocarboxazid |
|
|
Which MAO inhibitor is specific for MAO type A?
|
Clorgyline
|
|
|
What are the most common adverse effects of MAO inhibitors?
|
Drug interactions (serotonin syndrome)
Food interactions (tyramine) Sleep disturbances Orthostatic Hypotension Weight gain Sexual dysfunction |
|
|
What is a possible adverse food-drug interaction of tyramine-containing foods and MAO inhibitors?
|
Hypertensive crisis
|
|
|
What are some examples of SSRIs?
|
Fluoxetine (Prozac)
Clomipramine (Anafranil) Sertaline (Zoloft) Paroxetine (Paxil) Venlafaxine (Effexor) |
|
|
What is an example of an SSRI that has actions at both serotonin and norepinephrine receptors?
|
Venlafaxine (Effexor)
|
|
|
What are the most common adverse effects of SSRIs?
|
Diarrhea
Nausea Headache Insomnia Nervousness Fatigue Sexual Dysfunction |
|
|
What are the withdrawal effects of SSRIs?
|
Dizziness
Nausea Parathesias Palpitations Tremor Anxiety |
|
|
What are the adverse effects of MAOI/SSRI drug interactions?
|
SEROTONIN SYNDROME
Hyperthermia Diaphoresis Seizures Delirium |
|
|
What drug interactions can cause Serotonin Syndrome?
|
MAO inhibitors plus:
1) Clomiprimine 2) SSRI 3) Narcotics (Merpidine) |
|
|
What are the adverse effects of MAOI/Sympathomimetic drug interactions?
|
Hypertensive crisis
|
|
|
What are the adverse effects of MAOI/Opioid Analgesic drug interactions?
|
Hypertensive crisis
Circulatory collapse |
|
|
What are the adverse effects of MAOI/Buspirone drug interactions?
|
Hypertension
|
|
|
What are the adverse effects of MAOI/General anesthetic drug interactions?
|
Prolonged hypotensive and CNS depressive effects
|
