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13 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name TCAs
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Amitriptyline
imipramine clomipramine |
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Can TCAs be easily dialyzed?
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NO. high volume of distribution
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Name active metabolites of TCAs
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nortriptyline
desipramine |
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Name prototype SSRI
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Fluoxetine
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Half life of SSRIs. Why once weekly dosing of fluoxetine?
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18-24 hrs
Active metabolite has half life of few DAYS |
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Other members of SSRI
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citalopram
escitalopram paroxetine sertraline fluvoxamine |
NO LONG ACTING METABOLITE
"sita ke sar par flavour" |
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Name heterocyclic classes
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SNRIs - venlafaxine
Serotonin antags - trazodone Misc- bupropion, mirtazapine |
murtaza used to smoke
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What is unique about Serotonin antags?
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Nefazodone and trazodone have short half lives--> 2-3x daily dosing
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Name MAOIs
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phenelzine
tranylcypromine selegiline Similiar struct. to amphets |
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Differentiate MAO-A n MAO-B
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A- NE, 5HT, tyramine
B- DA |
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SNRIs vs. TCAs
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SNRIs:
Heterocyclic Do not have anti cholinergic, antihistaminic actions |
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MAOIs duration of action n dosing
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Tranylcypromine- 1wk
Others- 2-3wks BUT!!!! DAILY DOSING |
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Name selective MAO B inhibitor
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Selegeline
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