Anti-Depressant Drugs (Quiz 4)

Front 1

5 classes of anti-depressants

Back 1

- MAO inhibitors
- SSRIs
- SNRIs
- tricyclics
- atypical

Front 2

2 MAO inhibitors

Back 2

- phenelzine
- tranylcypromide

Front 3

6 SSRIs

Back 3

- citalopram
- escitalopram
- fluoxetine
- fluvoxamine
- paroxetine
- sertraline

Front 4

3 SNRIs

Back 4

- venlafaxine
- desvenlafaxine
- duloxetine

Front 5

3 TCAs

Back 5

- amitriptyline
- nortriptyline
- imipramine

Front 6

4 atyipcal anit-depressants

Back 6

- buproprion
- mirtazapine
- amoxapine
- trazodone

Front 7

class of phenelzine

Back 7

MAO inhibitor

Front 8

class of tranylcypromide

Back 8

MAO inhibitor

Front 9

class of citalopram

Back 9

SSRI

Front 10

class of escitalopram

Back 10

SSRI

Front 11

class of fluoxetine

Back 11

SSRI

Front 12

class of fluvoxamine

Back 12

SSRI

Front 13

class of paroxetine

Back 13

SSRI

Front 14

class of sertraline

Back 14

SSRI

Front 15

class of venlafaxine

Back 15

SNRI

Front 16

class of desvenlafaxine

Back 16

SNRI

Front 17

class of duloxetine

Back 17

SNRI

Front 18

class of amitriptyline

Back 18

TCA

Front 19

class of nortriptyline

Back 19

TCA

Front 20

class of imipramine

Back 20

TCA

Front 21

class of buproprion

Back 21

atypical (unicyclic)

Front 22

class of mirtazapine

Back 22

atypical (tetracyclic)

Front 23

class of amoxapine

Back 23

atypical (tetracyclic)

Front 24

class of trazodone

Back 24

atypical

Front 25

First line treatment for atypical depression

Back 25

MAO inhibitors

Front 26

Distinguishing feature between neuroleptic malignant syndrome (NMS) and serotonin syndrome

Back 26

hyperreflexia is present in serotonin syndrome

Front 27

3 drugs contraindicated with MAO inhibitors

Back 27

- other antidepressants
- methyldopa (alpha-agonist for HTN)
- dextromehorphan

Front 28

Which drugs are linked to tyramine-induced hypertensive crisis and what foods must be avoided?

Back 28

- MAO inhibitors
- aged meats, cheeses, red wines

Front 29

MOA of SSRIs

Back 29

- block presynaptic resorption of serotonin

Front 30

What is contraindicated with SSRIs

Back 30

- pimozide (anti-psychotic)
- use caution with other serotonergics

Front 31

What is MOA of SNRIs

Back 31

- low dose: function as SSRIs
- high dose: also block resorption of norepinephrine

Front 32

What anti-depressants are indicated for pain treatment?

Back 32

- SNRIs: neuropathic pain
- TCAs: chronic pain

Front 33

Which anti-depressants are associated with dose-dependant increases in diastolic BP

Back 33

- SNRIs

Front 34

MOA of TCAs

Back 34

- similar to SNRIs (block serotonin and norepinephrine)
- also block histamine and muscarinic acetylcholine receptors with high affinity

Front 35

What anti-depressants are indicated for chronic pain, HA, and nocturnal enuresis?

Back 35

TCAs

Front 36

What are main two side effects of TCAs?

Back 36

- anticholinergic (blurred vision, constipation, dry mouth, sedation, urinary retention, orthostatic hypotension)
- cardiovascular (tachycardia, prolonged QTc)

Front 37

MOA of buproprion

Back 37

unicyclic - inhibits reuptake of dopamine and norepinephrine

Front 38

MOA of mirtazapine and amoxapine

Back 38

tetracyclic - increases concentration of serotonin and norepinephrine

Front 39

MOA of trazodone

Back 39

5-HT2 agonist

Front 40

Which anti-depressants are indicated for MDD refractory to other treatments?

Back 40

MAO inhibitors

Front 41

Which anti-depressant is indicated for seasonal affective disorder

Back 41

buproprion

Front 42

What is severe SE of buproprion

Back 42

- seizures and psychosis

Front 43

What is severe SE of mirtazapine and amoxapine

Back 43

- agranulocytosis

Front 44

What is severe SE of trazodone

Back 44

- priapism

Front 45

What should be avoided specifically with buproprion?

Back 45

other dopaminergic agents

Front 46

What should be avoided with all atypical anti-depressants?

Back 46

- MAO inhibitors d/t risk of hypertensive crisis