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27 Cards in this Set
- Front
- Back
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Felbamate
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GABAa receptor agonists
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Phenobarbital
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↑ duration of GABAa R opening
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Topiramate
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GABAa receptor agonists and Na channel antagonist
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Benzodiazepines
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↑ frequency of GABAa R opening
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Valproate
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GABAa receptor agonists, Na channel antagonist, Ca channel antagonist
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Carbamazepine
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Na channel antagonist
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Zonisamide
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Na channel antagonist
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Valproate
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Na channel antagonist
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Topiramate
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Na channel antagonist
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Lamotrigine
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Na channel antagonist
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Phenytoin
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Na channel antagonist
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Oxcarbazepine
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Na channel antagonist
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What type of channel does ethosuximide affect?
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Ca channels (T-type)
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What type of channel does Gabapentine affect?
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Ca channels (L-type)
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How are absence seizures treated?
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Ethosuximide and Gabapentine
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Name the drug that is highly bound to albumin, drugs can compete it away to ↑ free drug, induce cyp450 metabolism
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Phenytoin
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For what type of seizure is carbamazepine used?
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complex partial seizures
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For what type of seizure is valproate used?
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all types in pediatric patients
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Which drugs are renally excreted?
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Pregabalin, Gabapentin, Levetiracetam
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Which drugs induce CYP metabolism?
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CBZ, PHT
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Which drugs inhibit CYP metabolism?
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VPA
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Which drugs are used to treat status epilepticus?
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Fosphenytoin, benzodiazepam (lorazepam)
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Which drug results in osteoporosis?
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CBZ, PHT
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Which drug causes bone marrow toxicity?
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CBZ
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Which drug causes amenorrhea?
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VPA
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Which drug causes rash?
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Lamotrigine
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Which drug(s) cause contraceptive failure?
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PHT, CBZ
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