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14 Cards in this Set
- Front
- Back
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MOA of penicillin (G,V)...
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bind PBP, block tanspeptidase cross-linking of cell wall, activate autolytic enzymes
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Toxicity of penicillins..
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hypersensitivity rxns (interstitial nephritiss), hemolytic anemia
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MOA of methicillin, naficillin, dicoxacillin... what makes them different from penicillin...
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bind PBP, prevent cross linking, activate autolytic enzymes. penicillinase resistant
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use of methicillin, naf, dicoxacillin...
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S.aureus, except MRSA
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ampicillin, amoxicillin MOA...
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bind PBP, prevent cross linking, activate autolytic enzymes. combine w/ clavulanic acid to enhance spectrum.
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clinical use of ampicillin/amoxicillin...
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H. influ, E. coli, Listeria, Proteus, Salmonella, enterococci (HELPS)
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1st generation cephalosporins and what they tx...
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Cefazolin, cephalexin. Treat PEK: proteus, E. coli, Klebsiella
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2nd gen cephalosporins and what they tx...
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cefoxitin, cefaclor, cefuroxime. tx: H. influ, Enterobacter, Neisseria, Proteus, E.coli, Klebsiella (HEN PEK)
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3rd gen cephalosporins and what theytx...
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ceftriaxone, cefotaxime, ceftazidime. Tx: serious gram - infxns resistant to other beta lactams; meninigitis (cross BBB), ceftazidime: Pseudo; ceftriaxone: Neisseria
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4th gen cephalo and what it tx:
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cefepime. incr activity against pseudo and gram positive organos
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aztreonam MOA and what it tx... what makes it special.
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monobactam resistant to b-lactamases. binds to PBP3. Treats the Az trio: Pseudo, Klebsiella, Serratia. Does not tx gram -'s or anaerobes. No cross allergenicity w/ pens and is synergistic w/ aminoglycosides
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toxicity of aztreonam...
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occasionaly GI. No cross-allergenicity w/ penicillins and is synergistic w/ aminoglycosides
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MOA of imipenem/cilastatin, meropenem... clinical use...
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broad spec, beta latamase resistant carbapenem. inhibits renal dihyropeptidase I to decr inactivation in renal tubules. Treats: gram + cocci, gram- rods, anaerobes. 1st line: enterobacter.
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toxicity of imipenem/cilastatin and meropenem...
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GI distress, skin rash, CNS toxicity, but meropenem has less siezure/CNS effects and is stable to dihyropeptidase I
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