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34 Cards in this Set
- Front
- Back
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Finasteride & Dutasteride Action/MOA
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Inhibits androgen synth (specifically DHT) by inhibiting 5-alpha reductase--> blocks conversion of T-->DHT
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Finasteride SE
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Teratogenicity to male fetus
Hypospadias Gynecomastia ED Androgen-sensitive hair growth |
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Finasteride & Dutasteride Use
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BPH; Hair loss in men
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Flutamide & Bicalutamide Action/MOA
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Inhibits androgen binding--> decreases action of endogenous Androgens-
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Flutamide & Bicalutamide Use
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Prostate cancer
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Cyproterone Action
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Decreases hirsutism in women
Decreases sex drive in men |
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Cyproterone MOA
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Anti-androgen w/ progestogenic effects
Inhibits LH |
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Ketoconazole Action/MOA
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Inhibits androgen synth in gonads and adrenal glands
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Ketoconazole SE
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Increased Liver enz
Rarely Hepatitis |
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Spironolactone Action
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Inhibits androgen receptors
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Spironolactone SE
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Hyperkalemia
Gynecomastia Met Acidosis Teratogenicity |
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Danazol Action/MOA
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Inhibits cytochrome P450 in gonadal steroid synth
Also a weak partial agonist of progestin, androgen, and glucocorticoid receptors |
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Nonoxynol-9 Action
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Spermicide
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Nonoxynol-9 MOA
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Attacks acrosomal membranes of sperm--> immobilize them!
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Phosphodiesterase Blocker for ED
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Sildenafil
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Sildenafil MOA
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blocks phosphodiesterase 5--> increases cGMP--> SM relaxation
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Sildenafil SE
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Syncope when used w/ NTG, MI from severely low BP
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PGE1 in ED (also for PDA in kids)
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Alprostadil
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Alprostadil Action
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SM relaxation (arterial)
Vasodilator Inhibits platelet aggregation!!!! |
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M3 Muscurinic Antagonist Action
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Decrease Urgency and bladder spasms
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Oxybutynin Class
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M3 Antagonist
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Tolterodine Class
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M3 Antagonist
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Solifenacin
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M3 Antagonist
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Darifenacin
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M3 Antagonist
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Beta agonist used for Overactive bladder
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Mirabegron
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Mirabegron Action/MOA
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Relaxes bladder SM by stimulating Beta-3 Receptor
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ADH Agonist used in Central Diabetes Insipidus
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Desmopressin
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Desmopressin Action
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Decreases urine volume
Vasoconstricion |
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Desmopressin MOA
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Water reabsorption in CCT by V1 & V2 activation--> sto, adenylyl cyclase via Gs--> increase cAMP--> adds more AQP2
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Alpha Agonist used as a Detumescent for priapism
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Phenylephrine
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Phenylephrine MOA
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Binds alpha-1 & alpha-2--> constriction of vessels entering penis
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Alpha-1 Antagonists used in BPH
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Tamsulosin
Alfuzosin |
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Tamsulosin SE
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Orthostatic Hypotension
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Tamsulosin and Alfuzosin Action in BPH
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SM relaxation
Improves urine flow |
