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15 Cards in this Set
- Front
- Back
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Clorsulon
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Inhibits glycolysis, used against blood and liver flukes
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Diamphenithide
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Inhibits glycolysis, used against blood and liver flukes
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SALICYLANILIDES
Closantel |
Proton ionophores, disrupt teguement of flukes, stop oxidative phosphorylation and uncouple proton gradient.
Bind to plama proteins |
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SUBSTITUTED PHENOLS
nitroxynil |
Proton ionophores, disrupt teguement of flukes, stop oxidative phosphorylation and uncouple proton gradient.
Bind to plama proteins |
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BENZIMIDOLES
Thiabendazole |
Bind to beta tubilin and inhibit microtublue polymerisation.
Stop mitosis and extretion, lower energy and allow host attack |
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Febantel -> Fenbendazole
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Bind to beta tubilin and inhibit microtublue polymerisation.
Stop mitosis and extretion, lower energy and allow host attack |
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Praziquantel
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Used against schistosomes, trematodes and flukes.
Absorbed and resecreted by Crypts of Lieberkuhn. Increases calcium permeability, by binding to beta subunit of chanel. Cause spastic paralsis and teguement damage |
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Paraherquamide
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Nicotinic receptor antagonist
Flaccid paralysis |
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AVERMECTINS
Ivermectin |
Broad spectrum, increase glutmate gated chloride permeability. Flaccid paralysis of pharynx and egg laying.
NOT to give to collies, mdr-1 lacks PgP and crosses BBB |
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Milbemycins
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Broad spectrum, increase glutmate gated chloride permeability. Flaccid paralysis of pharynx and egg laying.
NOT to give to collies, mdr-1 lacks PgP and crosses BBB |
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Piperazine
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GABAn receptor agonist, causes hyperpolariseationa nd flaccid paralysis. Does not have carboxyl group, only works in gut where -COOH is mimicked.
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Organophosphates
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Covalent P bond AChE at esteric site.
Spastic Paralysis |
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CARBAMATES
Aldicarb |
Carbamylate AChE
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IMIDAZOTHIAZOLES
levamisole |
nAChR agonist. Spastic paralysis and expulsion.
Soluble. |
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TETRAHYDROPYRIMIDINES
Pyrantel |
nAChR agonist. Spastic paralysis and expulsion. Not soluble, give as oral
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