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10 Cards in this Set
- Front
- Back
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What is the mechanism of Metyrapone?
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inhibits 11-hydroxylation interfering with cortisol and corticosterone synthesis
may prod. transient dizziness & GI disturbances |
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Which adrenal-inhibiting medication can be administered to pregnant women with Cushing's syndrome?
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Metyrapone
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What is the mechanism of Aminoglutethimide?
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blocks conversion of cholesterol to pregnenolone
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What is the mechanism of Ketoconazole?
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non-selective inhibitor of adrenal and gonadal steroid synthesis
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What is the mechanism of Mifepristone?
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binds to glucocorticoid receptor; strong antiprogestin activity
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What is the mechanism of Trilostane?
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3β-17 hydroxysteroid dehydrogenase inhibitor that interferes with the synthesis of adrenal and gondal hormones
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What is used to treat primary aldosteronism?
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Spirinolactone (50-100 mg/d); also an androgen antagonist used to treat hirsutism
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What are the adverse effects of spirinolactone?
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hyperkalemia, cardiac arrhythmia, menstrual abnormalities, gynecomastia, sedation, headache, GI disturbances, and skin rashes
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indication of Eplerenone
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hypertension (50-100 mg/d)
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What is Drospirenone?
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oral contraceptive; also antagonizes the effects of aldosterone
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