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39 Cards in this Set

  • Front
  • Back
Idiopathic thrombocytopenic purpura - caused by..?
Antibodies against platelets, splenic destruction of opsonized platelets, usually following a viral upper respiratory tract infection
This enzyme is active during VDJ rearrangement in lymphocytes....marker of primitive cells in cancer?
Terminal deoxynucleotidyl transferase
Cytoplasmic mu chain expression indicates that a lymphocyte has undergone...?
VDJ rearrangement
Describe MCV, MCH, and MCHC of B12 anemia?
High MCV, High MCH, and normal MCHC
Target cells are most commonly seen in...?
Thalassemia, hemoglobin C, and liver disease
CLL is a disease of which age group?
Older adults - 65
Acute monocytic leukemia - what FAB classification?
Hepatic chirrhosis is associated with which changes in the spleen?
Thickened capsule and many small, scarred areas with fibrosis with hemosiderin and calcium deposition
Which subtype of AML could lead to DIC? How?
M3 - during tx as a cnosequence of release of granules (Auer rods) from cells in the promyelocytic line
Crew haircut appearance of the skull is due to which conditions?
Sickle cell anemia, thalassemia
which translocations are associated with Burkitt lymphoma?
8;14, 8;22, 2;8
Stage III Hodgkins with constitutional symptoms gets staged how..?
Stage IIIB
Describe serum levels of iron, ferritin, and transferrin in iron deficiency anemia?
Serum iron and ferritin is decreased, while transferrin is increased
Translocation seen in the follicular type of small cleaved cell (B cell) lymphoma?
Reed Sternberg cells express which CDs?
CD15 and CD30
Lacunar cells are seen in which type of Hodgkin disease?
Nodular sclerosing variant
Which autoimmune disease is a significant cause of thyombocytopenia?
Acute promyelocytic leukemia is associated with which translocation?
This disease causes purpura, fever, renal failure, MAHA, and microthrombi, frequently in young women..?
Thrombotic thrombocytopenic purpura
T or F? All lympgomas are monoclonal.
Defects in platelet adhesion are seen in which diseases?
von Willebrand's and Bernard-Souliier
T or F? Aspirin therapy interferes with secondary platelet aggregation.
This disease produces a self-limited granulomatous response in the draining lymph nodes...can be due to pets..?
Bartonella henselae - cat-scratch disease
Coadministration of warfarin and which antibiotic could produce pronounced anticoagulation and hematuria?
Clarithromycin, norfloxacin
T or F? In both thrombasthenia and vW disease, the platelet count will be normal, although platelet function is impaired.
This agent is primarily used to treat CLL and ovarian carcinoma?
What type of kidney stones would be expected in a patient undergoing tx for ALL?
Uric acid kidney stones
What cells predominate in a blood film of an infectious mono patient?
Reactive T cells
Most common cause of drug-induced thrombocytopenia?
Hereditary spherocytosis is associated with a defect in..?
Structural proteins such as spectrin and ankyrin
Relapse in plasmodium infections are due to dormant forms of the organisms called...?
This medication can cause sharply demarcated, erythematous, and pupuric lesions, which can progress to large hemorrhagic bullae...
Characteristics of Bartonella henselae?
Gram-negative bacillus
What are D-dimers?
Fibrin split products
Lymphatic fluid from the lateral aspect of the dorsum of the foot drains to...?
Lymph nodes in the popliteal fossa
Clues: One week incubation period, Eastern seaboard, and intra-erythrocyte protoza..?
Babesia microti
Eosinophil granules contain which protein in their crystalline cores?
Major basic protein
Platelet count needs to be less than ......... before generalized bleeding usually occurs?
Parvoviruses cause which three distinct syndromes?
1. Fifth disease (erythema infectiosum)
2. Aplastic crisis in Sickle cell anemia, thalassemia, etc
3. Congenital infections - stillbirth, hydrops fetalis, anemia