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26 Cards in this Set
- Front
- Back
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Name 5 fxs of the ANS
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1) BP control 2) GI motility/secretion 3) urinary bladder 4) temperature 5) sweating
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Where does activation of the ANS occur?
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SC, Brainstem and hypothalamus
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Describe the conversion of dopamine to norepi
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1) Dopamine is formed in the cytoplasm 2) it enters the synaptic vesicle 3) Dopamine b-hydoxyalase converts it to norepi.
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What couples the AP with the release of the synaptic vessel?
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Ca++
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What is the length of stimulation of NE?
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Brief, d/t reuptake/breakdown/diffusion
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Describe the formation of ACh
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choline [from the ECF] + AcetylCoA [from mitochondria] meet in the cytoplasm + choline acetyltransferase -> ACh
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Describe the breakdown of ACh
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ACh + ACE -> Acetic acid + choline [choline is recycled for more ACh]
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What is the difference between ACE and PseudoCE?
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ACE is found predominantly at synapse, where PseudoCE is found in plasma
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Where are a1 receptors located?
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postsynaptic, smooth muscle
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Where are a2 receptors located?
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presynaptic; platlets, lipocytes & smooth muscle
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Where are b1 receptors located
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postsynaptic cardiac
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Where are b2 receptors located?
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postsynaptic cardiac & smooth muscle
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Where are dopamine-1 receptors located?
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Postsynaptic brain, smooth muscle of renal vasculature
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Where are dopamine-2 receptors located?
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presynaptic brain, smooth muscle
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Where are dopamine 3 receptors located
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brain
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Where are dopamine-4 receptors located
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brain, heart
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What is the effect of D2 stimulation?
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Negative feedback - stimulation leads to inhibition of firing
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Which adrenergic receptors work by Gs -> increased cAMP?
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B1, B2, D1
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Which adrenergic receptors work by Gi -> decreased cAMP
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A2, D2
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Describe the different types of nicotinic receptors
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N1/Nn: On ANS postganglionic neurons; N2/Nm: NMJ
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Where is the M1 receptor located
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autonomic ganglia and CNS
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Where is the M2 receptor located?
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Myocardium, salivary glands, various presynaptic sites
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Where is the M3 receptor located?
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exocrine glands, smooth muscle vessel
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Describe the M4 receptors
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In CNS; responsible for analgesia, cataleptic activity, facilitation of dopamine release
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Describe M5 receptors
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In CNS/periphery; mediator of dilation in cerebral arteries, facilitates dopamine release, augmentation of drug-seeking behavior
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Describe the effect of M2 receptors in the presence of ACh
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Inhibitory effects -> bradycardia.
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