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9 Cards in this Set
- Front
- Back
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What are SEs of alpha blockade?
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Orthostatic hypotension, baroreceptor-mediated tachycardia, sexual dysfunction
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What is the issue with alpha blockade in the absence of beta blockade?
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Norepi unopposed -> increased cardiac stimulation
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Describe phentolamine
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Nonselective a-blocker, fast-acting/short t1/2,
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What is the clinical use of phentolamine?
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Hypertensive emergencies, phenochromacytoma, autonomic dysreflexia
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Describ phenoxybenzzamine
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Non-selective a-blocker, but a1>a2. Covalent modification of receptor. Oral PO for pheo.
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Describe Yohimbine
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Selective presynaptic a2 blocker -> enhanced release of NE. Used for orthostasis
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Describe Prazosin
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Selective a1 blocker (but no a2 -> continued NE release -> no reflex tachy)
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Describe Terazosin
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Like prazosin, but less potent. Used for BPH
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Should beta-blockers be continued perioperatively?
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Yes, to prevent w/drawl, oversensitvity w/ upregulation
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