Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
Alphamethyl-DA
|
Dopa decarboxylase inhibitor (dec production of DA, E, and NE). Reduced DA and adrenergic effects. Treats: hypertension. Side effects: CNS--depression, anxiety, parkinsonism
|
|
|
Alphamethyl-NE
|
Metabolized from Alphamethyl-DA. a2-R agonist. Activates inhibitory autoR and heteroR, resulting in suppression of sympathetic effects. Treats: hypertension
|
|
|
atenolol
|
b1 selective antagonist. Treats: CV disease. Side effects: no CNS effects
|
|
|
Atropine
|
competitive antagonist for mAchR. PS->effector blocker.
|
|
|
Clonidine
|
a2 selective agonist. stimulates a2R in vasomotor center of brainstem, decreasing CO and peripheral resistance. Treats: hypertension.
|
|
|
cocaine
|
inhibit NT reuptake in dopaminergic neurons. (cocaine paradox--> cocaine enhances effects of NE -> hypertension)
|
|
|
dobutamine
|
b1 selective agonist
|
|
|
DOPA
|
converted by dopa-decarboxylase -> dopaine. Treats: PD
|
|
|
Ephedrine
|
mixed sympatomimetic. weakly activates a-R and b-R. packaged with NE and increases release of NE.
|
|
|
epinephrine
|
Non-selective agonist of a and b R. released by adrenal medula.
|
|
|
isoproterenol
|
b1 and b2 agonist. used to treat bradycardia (b1, b2) and used to be used to treat asthma (b2, relax airways). It produces vasodilation in arteries (b2), and increases cardiac output (b1)→ increase systolic bp and decrease diastolic.
|
|
|
Neostigmine
|
AchE inhibitor. Used to treat myasthemia gravis. Used with anti-cholinergics to block PS-effector junction while retaining effect at NMJ.
|
|
|
Norepinephrine
|
a and b1-selective agonist. released by postgang symp neurons and adrenal medulla.
|
|
|
Phentolamine
|
nonselective a-R antagonist
|
|
|
phenylphrine
|
a1-R agonist. Used as decongestant, pupil dilator, increase bp
|
|
|
pilocarpine
|
mAchR agonist. Treats: open-angle glaucoma. Increased PS-> open canal of schlemm -> dec intraoccular pressure.
|
|
|
prazocin
|
a1 R antagonist. Treats: hypertension.
|
|
|
propranolol
|
non-selective B antagonist. Treats: arrythmias. Cross BBB so has cns effects.
|
|
|
Reserpine
|
inactivates the pump that accumulates NE in vesicles. Inhibits sympathetic function. Treats: hypertension. Side effects: Parkinsonism, depression.
|
|
|
Terbutaline
|
B2 selective agonist. Treats: asthma and COPD (bronchodilation) and preterm labor (uterine relaxation).
|
|
|
Tranylcypramine
|
nonspecific inhibitor for monoamine oxidase (MAO), preventing metabolism of biogenic amines.--> hypertension
|
|
|
alpha responses
|
- vasoconstriction
- eye radial mm constriction (pupillary constriction) - piloerection - gut relaxation - CNS effects |
|
|
B responses
|
- vasodilation
- cardiac stimulation - bronchodilation - gut relaxation - uterine relaxation - renin release |
|
|
b1 - 3 responses
|
b1: heart and renin
b2: vasodil, bronchodil, uterine relaxation, gut relaxation b3: lypolysis and bladder relax |
|
|
NE:
effect on BP, Pulse, Peripheral R. |
BP: increased systolic and diastolic.
Pulse: slight decrease (reflex) Resistance: increased (hit a and b1, doesnt hit b2 R--no vasodil, only increased cardiac output) |
|
|
E:
effect on BP, Pulse, Peripheral R. |
BP: increased systolic and decreased diastolic (balance of vasodil and vasoconstriction)
pulse: increase (b1) resistance: decrease (b2 > a) (hit all alpha and beta) |
|
|
Isoprotenenol:
effect on BP, Pulse, Peripheral R. |
BP: slight increased systolic and decreased diastolic
Pulse: increased (b1) Resistance: decreases a lot (b2) (only hits b receptors, no vasoconstriction) |
