Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
|
What are the risk factors for ankylosing spondylitis?
|
HLA-B27, B60 and DR1
Male Family history Gram-negative infection |
|
|
What are the clinical features of ankylosing spondylitis?
|
Episodic inflammation of SI joint
Pain and stiffness in buttocks and lower back Reduced chest expansion Paraspinal muscle wasting Asymmetrical peripheral large joint involvement Enthesitis - calcification at ligament insertion Uveitis Costochondritis IHD Uritis Conjunctivitis Fibrosis and restrictive lung disease Fatigue |
|
|
How is ankylosing spondylitis diagnosed?
|
in under 50s 3/4 of:
morning stiffness >3 minutes Improvement of pain with exercise Awakening due to back pain in 2nd half of night Alternating buttock pain |
|
|
What investigations are carried out for ankylosing spondylitis?
|
Raised ESR and CRP
X ray - SI erosion and sclerosis, blurring of vertebral rims, bony spurs, bamboo spine MRI - early sacroiliitis |
|
|
How is ankylosing spondylitis treated?
|
Early diagnosis
Prevention exercise NSAIDS or steroid injection Methotrexate TNF-alpha blocking drugs |
