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21 Cards in this Set
- Front
- Back
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What is the definition of growth factor?
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Chemical substances usually polypeptides, that are secreted by cells present in serum. They stimulate cellular growth
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What is the role and function of EGF.
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Present in secretions and fluids (saliva). Mitogenic for many epithelial cells and fibroblasts
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Platelet-derived growth factor (PDGF) what is the role and function?
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Induces proliferation as well as migration of monocytes, fibroblasts and smooth muscle cells. Present in platelet, alpha granules, macrophages, endothelial cells, smooth muscle cells and some tumor cells.
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Where is Transforming growth factos α and β found? What is their function?
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It is produced by many cells (eg. T cells, macrophages, platelets, and endothelial cells. Helps repair by stimulation fibroblast chemotaxis and production og collagen and fibronectin
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Where is acidic fibroblast growth factor (FGFs) found
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Confined to neural tissues
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Where is basic fibroblast growth factor found?
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Present in many organs. Its role is an angiogenesis promoting factor
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What role do macrophage derived cytokines such as IL-1, TNF and integrins play in the processes of angiogenesis?
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They can promote proliferation of fibroblasts
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What are the different types of colony stimulating factors?
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Granulocyte CSF, macropahe CSF, and granulocyte-macrophage CSF
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What is the function of Colony-stimulating factors?
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Stimulate bone marrow formation, especially in leukemia and bone marrow transplantation regimens
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What are adhesive glycoproteins?
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Group of glycoproteins that link components of the extracellular matrix together and to the cells
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What forms fibronectin?
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Fibroblasts and endothelial cells
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What is fibroenctin?
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Large glycoprotein, involved in the attachment and migration of cells, and probably in cellular growth and is present along cekk surface and basement membranes
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What is an integrin?
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Adhesive Transmembrane glycoprotein with extracellular and intracellular domains
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What is the function of integrins?
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Signals attachment and locomotion
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What is the most common adhesive glycoprotein in the basement membrane?
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laminin
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What is the function of laminin?
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Binds extracellular matrix components to specific cell surface receptors and assists in capillary tube formation in angiogenesis
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What is the function Chondronectin
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Binds the chondrocytes to type II collagen in the cartilage matrix
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What is the role of osteonectin?
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Binds the hydroxypatite and calcium ions to type I collagen in the bone matrix and can initiate osteoid mineralization
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What is one of the initial steps of angiogenesis?
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Degredation of the basement membrane of the parent vessel followed by migration of endothelial cells
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Once the endothelial cells have migrated in the beginning processes of angiogenesis. What occurs next?
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Endothelial cells finally create newly formed capillary tubes.
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What are some of the factors that induce angiogenesis?
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FGF, and VEGF
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