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12 Cards in this Set
- Front
- Back
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Angina
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Myocardial ischaemia - myocardial o2 demand is not being met.
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Stable angina?
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Most common
Predictable - exercise or stress o2 demand met when at rest Involved in coronary heart disease |
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Unstable angina?
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Attacks are unpredictable
Coronary artery occlusion due to platelet adhesion to atheroschlorotic plaque Unstable plaque |
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Variant angina?
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Unpredictable
Vasospasm |
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Propanolol
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B1 & B2 reversible antagonist
--> lowers HR & force therefore lower work therefore lower o2 demand. |
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Atenolol
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B1 selective
-->lowers HR & force therefore lowers the workload therefore lowers the myocardial o2 demand |
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Ivabradine
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Blocks Na current that contributes to the SA node depolarisation towards threshold (block na entry)
--> decreases HR but not force. Useful in all forms of angina |
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Glyceryltrinitrate
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Nitrovasodilator
Prophylaxis - taken before exercise Lipophilic Taken sublingually to bypass first metabolism of the liver. |
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Nitrodilators
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Pro drugs
Lipophilic --> binds to heme receptor > activates guanylate cyclase >cGMP > vasodilation. |
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side effects of nitrovasodilators
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- headache: dilation of cerebral arteries
- tolerance: cells stop producing NO |
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Function of L type voltage gated calcium channels
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Calcium entry therefore contraction of smooth muscle & cardiac muscle.
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Blockers of voltage gated calcium channel
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Block: Verapamil & Diltiazem
Allosteric: Nifedipine |
