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9 Cards in this Set
- Front
- Back
MAC
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Minimum Alveolar Concentration required to inhibit movement in 50% of patients (ED50).
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Meyer-Overton Rule
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Anesthetic potency is related to lipid solubility.
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What is the goal of anesthetic administration?
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To establish a critical partial pressure in CNS.
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Compared with insoluble anesthetics, more soluble anesthetics
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Have higher lung uptake
Require more molecules to be “dissolved” in the brain to exert a given partial pressure |
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Nitrous oxide
Halothane Sevoflurane Isoflurane Desflurane |
Inhaled anesthetics
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What are some side effects of inhaled anesthetics, such as halothane?
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Hepatic and malignant hypothermia (abnormality of ryanodine receptor in SR, treated with dantrolene)
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What are some concerns about the use of thiopental?
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Respiratory depression, decreased contractility, slow metabolism (although ephemeral anesthetic affect).
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What are some concerns about the use of Propofol?
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Respiratory depression, decreased contractility. Better than thiopental, but may cause pain upon injection.
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What are some concerns about the use of Ketamine?
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psychic effects. given to uncooperative patients by IM injection, no respiratory or cardiac depression.
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