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9 Cards in this Set

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MAC
Minimum Alveolar Concentration required to inhibit movement in 50% of patients (ED50).
Meyer-Overton Rule
Anesthetic potency is related to lipid solubility.
What is the goal of anesthetic administration?
To establish a critical partial pressure in CNS.
Compared with insoluble anesthetics, more soluble anesthetics
Have higher lung uptake
Require more molecules to be “dissolved” in the brain to exert a given partial pressure
Nitrous oxide
Halothane
Sevoflurane
Isoflurane
Desflurane
Inhaled anesthetics
What are some side effects of inhaled anesthetics, such as halothane?
Hepatic and malignant hypothermia (abnormality of ryanodine receptor in SR, treated with dantrolene)
What are some concerns about the use of thiopental?
Respiratory depression, decreased contractility, slow metabolism (although ephemeral anesthetic affect).
What are some concerns about the use of Propofol?
Respiratory depression, decreased contractility. Better than thiopental, but may cause pain upon injection.
What are some concerns about the use of Ketamine?
psychic effects. given to uncooperative patients by IM injection, no respiratory or cardiac depression.