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30 Cards in this Set

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  • Back
drugs with what type of solubility in blood have rapid induction and recovery times?
decreased solubility
drugs with what solubility in lipids have increased potency?
increased solubility
the greater the MAC, the what?
greater the concentration needed to produce anesthesia
what inhaled anesthetic is associated with hepatotoxicity?
halothane
what inhaled anesthetic is associated with nephrotoxicity?
methoxyflurane
what inhaled anesthetic is a proconvulsant?
enflurane
what is the Rx for malignant hyperthermia?
dantrolene
this class of intravenous anesthetics causes decreased cerebral blood flow and is therefore desirable for patients with cerebral edema
barbiturates
this IV anesthetic class can cause exacerbation of intermittent porphyria
barbiturates
what is the most common anesthetic used for endoscopy?
midazolam
this class of IV anesthetics can cause severe post-op respiratory depression, decreased BP, and amnesia? what do you treat this with?
benzodiazepenes; flumazenil
this class of anesthetics are PCP analogs that act as dissociative anesthetics
arylcyclohexamines, e.g. ketamine
these anesthetics can cause disorientation, hallucination, and bad dreams
arylcyclohexamines (ketamine) - also increase cerebral blood flow
what reverses the CNS and respiratory effects of opiods?
naloxone
this IV anesthetic has less post-op nausea than thiopental
propofol
this IV anesthetic is used for rapid anesthesia induction and short procedures
propofol
procaine, cocaine, tetracaine belong to what class of local anesthetic?
esters
lidocaine, mepivacaine, bupivacaine belong to what class of local anesthetic
amides - amides have 2 i's in name
how do local anesthetics work?
block Na+ channels by binding to specific receptors on inner portion of cannel; tertiarty amines penetrate membranes in uncharged form, then bind to ion channels in charged form
why do you need more local anesthetic in infected tissues?
infected tissues is acidic, so anesthetics are charged and cannot penetrate membrane effectively
what is the order of loss with local anesthetics?
pain > temperature > touch > pressure
what local anesthetic has severe CV toxitcity?
bupivacaine
what local anesthetic is associated with hypertension, hypotension, and arrhythmias?
cocaine
what is the mechanism of action of dantrolene?
prevents the release of Ca2+ from the sarcoplasmic reticulum of skeletal muscle
what kind of drug is succinylcholine?
depolarizing NM blocker
what is the antidote for phase I NM block?
none - block is potentiated by cholinesterase inhibitors
what is the antidote for phase II NM block?
cholinesterase inhibitors, e.g. neostigmine
how do you reverse nondepolarizing NM blockade?
neostigmine, edrophonium, and other cholinesterase inhibitors
what class of drugs do tubocurarine, atracurium, mivacurium, pancuronium, vercuronium, rapacuroniumm belong to?
nondepolarizing NM blockers
what type of NM blockers compete with ACh for receptors?
nondepolarizing