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13 Cards in this Set
- Front
- Back
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Major Opoid Receptor Subtypes (4)?
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1. Mu
2. Kappa 3. Delta 4. Sigma |
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Which opoid receptor subtype causes generally unwanted clinical effects?
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1. Sigma Subtype
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Opoid Kappa Receptor
1. Effects |
1. Sedation, spinal analgesia
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Opoid Mu Receptor
1. Effects |
1. Supraspinal (Mu1) analgesia, resp depression (Mu2), muscle rigidity, dependance
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Opoid Delta Receptor
1. Effects |
1. Analgesia, behavioral, elleptogenic
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Opoid Sigma Receptor
1. Effects |
1. Dysphoria, hallucinations, resp stimulation
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Morphine
1. Dose 2. Onset 3. Duration |
1. 0.1 mg/kg
2. Slow (20 mins) 3. Long (24 hrs) |
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Potency of Narcotics (described in dose)?
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Morphine 0.1 mg/kg
Hydromorphone 0.01 mg/kg Fentanyl 0.001 mg/kg (1 mcg/kg) *Hydromorphone is 10x more powerful than morphine and fentanyl is 10x more potent than hydromorphone |
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Fentanyl
1. Dose 2. Concentration 3. Onset 4. Duration |
1. 1 mcg/kg (0.001 mg/kg)
2. 50 mcg/mL 3. Quick (5 mins) 4. Short (2 hrs) |
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Morphine
1. Metabolites 2. AEs |
1. Morphine-6-glucoronide (ACTIVE) and M-3-G (inactive)
2. Histamine release (lowers MAP), resp depression - can increase ICP b/c inc CO2, stiff chest, Oddi dysfxn (treat with nitro/naloxone), delayed gastric emptying, N/V (activates DA receptors in chemo rec trig zone) |
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Why is Fentanyl's duration of action shorter than morphines?
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1. Redistribution into peripheral tissues (very lipid soluble!)
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Fentanyl
1. AEs |
1. NO HISTAMINE REALEASE, CV depression (only with pretreatment with benzos - otherwise can be used for cardiac induction of anesthesia)
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Meperidine
1. Dose 2. Onset 3. Duration 4. Clinical use 5. AEs |
1. 0.5 mg/kg
2. 5 mins 3. 5 hrs 4. Shivering 5. Normeperidine (metabolyte) can cause seizures, ortho HoTN, drug interaction with MAOIs |
