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24 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Propofol
1. Dose 2. Concentration 3. Onset 4. t1/2 |
1. 3 mg/kg
2. 10 mg/mL 3. 30 sec 4. 5 mins |
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Etomidate
1. Dose 2. Concentration 3. Onset 4. t1/2 |
1. 0.3 mg/kg
2. 2 mg/mL 3. 30 sec 4. 10 mins |
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Ketamine
1. Dose 2. Concentration 3. Onset 4. t1/2 |
1. 1 mg/kg
2. ?? 3. 1 min 4. 15 mins |
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Thiopental
1. Dose 2. Concentration 3. Onset 4. t1/2 |
1. 4 mg/kg
2. ?? 3. 30 sec 4. 20 mins |
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Propofol
1. CV effects |
1. DEPRESSANT
2. Decrease in MAP from decrease in SVR 3. INHIBITS BAROREFLEX |
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Propofol
1. Resp effects |
1. DEPRESSANT
2. Deprresses airway reflexes (makes easier to DL) |
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Propofol
1. Neuro effects |
1. DECREASES ALL (CMRO2, ICP, CBF)
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Propofol
1. Ophtho effects |
1. Lowers IOP
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Propofol
1. Summary of effects on CV, resp, neuro, and ophtho. |
1. DEPRESSES ALL!!
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Propofol
1. Unique aspects |
1. made with egg yolk
2. pain on injection 3. Anti-emesis and pruritic properties |
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Etomidate
1. CV |
1. Minimal! Very CV stable
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Etomidate
1. Resp |
1. THEY KEEP BREATHING during induction
2. Doesn't supress symp resp to DL |
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Etomidate
1. Neuro |
1. Decreases ICP, CMRO2, and CBF but can cause SEIZURES
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Etomidate
1. Unique aspects |
1. Adrenal Supression (11-bets hydroxylase)
2. pain on injection 3. Post-op N/V 4. SEIZURES (even though has been used to treat them) |
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Etomidate
1. Summary of effects on CV, Rest, Neuro |
1. Minimal effect on CV and Resp. Decreases Neuro but can cause seizurres.
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Etomidate
1. Metabolism |
1. Hepatic ester hydrolysis
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Ketamine
1. CV effects |
1. INCREASES due to stimulation of SNS (but in times of catacholamine depletion - shock/spinal anesthesia - pts won't have this response and can have HoTN.
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Ketamine
1. Resp effects |
1. Minimal Change
2. SALIVATION (pretreat with glyco) 3. Airway reflexex remain intact |
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Ketamine
1. Neuro effects |
1. Dissociative amnesia (looks awake)
2. Can be prevented by pretreatment with benzos 3. INCREASES CBF, CMRO2, and ICP. 4. Also increases IOP |
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Ketamine
1. MOA |
1. NMDA receptors (others work at or around GABA)
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Thiopental
1. CV effects |
1. Direct negative inotrope and decreases SVR
2. Causes low MAP, tachycardia, low contractility |
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Thiopental
1. Resp effects |
1. Some mild depression
2. BRONCHOSPASM - due to histamine release |
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Thiopental
1. Neuro effects |
1. Decrease in all (CBF, CMRO2, and ICP) but drop in ICP greater than MAP so CPP increases.
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Thiopental
1. Unique aspects |
1. Highly protein bound (malnutrition will increase effect)
2. Inducible PORPHYRIA by stimulating ALA synthetase 3. Garlic & Onion taste on induction |
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