Anesthesia Chemotherapy Drugs

Front 1

Forms covalent bonds between alkyl groups & nucleophillic groups of proteins. Bonds 7-nitrogen group of guanine; cross links DNA strands so that they do not separate as required and results in cell death: non phase specific

Back 1

Alkylating Agents

Front 2

Are cytotoxic, teratogenic, and myelosupressive as a class. Bone marrow suppresion is most important dose-limiting factor.

Back 2

Alkylating Agents

Front 3

Are alkylating agents.
Can be oral or IV.
Effective for lymphomas/leukemias.
1% fibrosing pneumonitis-delayed rx.
Watch overhydration--5-10% hemorrhagic cystitis-give Mesna, bind toxic metabolite.

Back 3

Cyclophosphamide and Ifosfamide
(are nitrogen mustard)

Front 4

Alkylating Agent.
Nitrosoureas.
Highly lipophilic--cross BBB (CNS Ca)
IV or drug-impregnated biodegradable wafer.

Back 4

Carmustine (BCNU)
Lomustine (CCNU)

Front 5

Dose related cummulative glomerulosclerosis effect (nephrotoxic),
For high doese can see up to 30% pulmonary fibrosis,
Delayed myleosuppression: thrombocytopenia > neutropenia.

Back 5

Alkylating Agents - Nitrosoureas.
(Carmustine & Lomustine)

Front 6

Decarbazine (IV)
Temozolomide (PO)

Back 6

Nonclassic Alkylating Agents
(Triazenes)

Front 7

Side effects:
Mild-moderate N/V which gets better with subsequent doses.
Mild-mod myelosuppression.
Sever headache prevalent 25%.
Increased LFT's can occur with either drug.

Back 7

Decarbazine (IV)
Temozolomide (PO)

Front 8

Very useful, but requires supportive treatement.
Platinum forms DNA intrstrand cross-links that cause major DNA bend.
Dose limiting factor is renal toxicity.

Back 8

Platinating Agents

Front 9

Cisplatin
Carboplatin
Oxaliplatin

Back 9

Platinating Agents

Front 10

2 similar drugs, adverse rx include: nephro/ototoxic; neuropathies, increased N/V, some seizures, arrythmias

Back 10

Cisplatin
Carboplatin