Anemias

Front 1

What is the fundamental defect in pernicious anemia?

Back 1

The fundamental defect of pernicious anemia is the lack of intrinsic factor. Without it B12 cannot be absorbed leading to B12 deficiency.

Front 2

What is the cause(s) of iron deficient anemia?

Back 2

The causes of iron deficient anemia may be due to low iron intake, diminished absorption, physiologic increased requirements of pregnancy, excessive iron loss from chronic or acute hemorrhage, or chronic renal failure.

Front 3

Which anemia is inherited disorder of red cells, characterized by decreased red cell survival rates?

Back 3

Thalassemia is an anemia of red cells, characterized by decreased red cell survival rates. The red cells produced are abnormal and prone to destruction. The destruction is based on an intrinsic defect in the cells.

Front 4

___________ is a group of diseases associated with the presence of mutant genes that suppress the rate of synthesis of globin chains?

Back 4

Thalassemias

Front 5

Which anemia is an inherited recessive X-linked disorder?

Back 5

Sickle cell anemia is a genetically determined defect of hemoglobin synthesis.

Front 6

Under decreased oxygen tension, hemoglobin S undergoes polymerization, which causes the red cell to assume this shape. Name the anemia.

Back 6

Sickle Cell Anemia. The shape is "sickled"

Front 7

___________, is an inherited autosomal dominant disorder of factor VIII carrier protein and platelet dysfunction.

Back 7

von Willebrand disease. In vWD, the level of vW factor is decreased to absent; factor VIII may be mildly to severely depressed. Absence of platelet adhesion at the site of vascular injury and deficient factor VIII activity in the intrinsic coagulation pathway contribute to the bleeding seen in von Willebrand disease.