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11 Cards in this Set
- Front
- Back
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When do term infants reach their physiologic nadir in hemoglobin level?
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8 to 12 weeks after birth.
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When does anemia of prematurity occur?
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typically occurs at 3 to 12 weeks after birth in infants less than 32 weeks gestation and resolves spontaneously by three to six months
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what symptoms are associated with AOP?
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May not be symptomatic; may develop tachycardia, poor weight gain, increased requirement of supplemental oxygen, or increased episodes of apnea or bradycardia.
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What are the indices like in AOP?
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Normocytic, low retic count
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Why does AOP occur?
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Decrease erythropoietin production
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Where is EPO produced in the fetus?
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Principally in the Liver; also in the cortical interstitial cells of the kidney
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What does 2,3 biphosphoglycerate (2,3-BPG, also called 2,3-diphosphoglycerate or 2,3-DPG) do?
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It is a potent modulator of the affinity of hemoglobin for oxygen. Increasing levels of 2,3-BPG decrease the oxygen affinity, shift the oxyhemoglobin dissociation curve to the right, and increase the delivery of oxygen to tissues
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Why does HgF have higher oxygen affinity than adult hemoglobin?
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HgF binds 2,3-BPG poorly
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How does AOP affect an infant with BPD?
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It is associated with increased stroke volume and shortening fraction, as well as heart rate and cardiac output
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How is AOP treated?
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usually with red blood cell transfusions. Recombinant human EPO may be used in some circumstances.
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How is iron supplemented for premature babies?
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2 mg/kg per day
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