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11 Cards in this Set

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When do term infants reach their physiologic nadir in hemoglobin level?
8 to 12 weeks after birth.
When does anemia of prematurity occur?
typically occurs at 3 to 12 weeks after birth in infants less than 32 weeks gestation and resolves spontaneously by three to six months
what symptoms are associated with AOP?
May not be symptomatic; may develop tachycardia, poor weight gain, increased requirement of supplemental oxygen, or increased episodes of apnea or bradycardia.
What are the indices like in AOP?
Normocytic, low retic count
Why does AOP occur?
Decrease erythropoietin production
Where is EPO produced in the fetus?
Principally in the Liver; also in the cortical interstitial cells of the kidney
What does 2,3 biphosphoglycerate (2,3-BPG, also called 2,3-diphosphoglycerate or 2,3-DPG) do?
It is a potent modulator of the affinity of hemoglobin for oxygen. Increasing levels of 2,3-BPG decrease the oxygen affinity, shift the oxyhemoglobin dissociation curve to the right, and increase the delivery of oxygen to tissues
Why does HgF have higher oxygen affinity than adult hemoglobin?
HgF binds 2,3-BPG poorly
How does AOP affect an infant with BPD?
It is associated with increased stroke volume and shortening fraction, as well as heart rate and cardiac output
How is AOP treated?
usually with red blood cell transfusions. Recombinant human EPO may be used in some circumstances.
How is iron supplemented for premature babies?
2 mg/kg per day