Anemia Drugs Block 3

Front 1

Agents used in anemias

Back 1

iron, iron chelating agents, vitamin B 12, folic acid

Front 2

Iron

Back 2

iron salts, iron dextran, iron sucrose complex, iron sodium gluconate complex

Front 3

iron chelating agents

Back 3

deferoxamine, deferasirox

Front 4

vitamin B12

Back 4

cyanocobalamin, hydoxocobalamin

Front 5

iron salts

Back 5

Fe sulfate, gluconate, fumarate

Front 6

Iron

Back 6

for treatment of iron deficiency anemia

Front 7

iron should not be used in

Back 7

hemolytic anemia unless severe iron deficiency is confirmed

Front 8

common causes of iron deficiency

Back 8

blood loss, GI bleeding

Front 9

Common side effects of oral iron therapy

Back 9

black stool, dose related nausea, epigastric discomfort, abdominal cramps, constipation, diarrhea

Front 10

oral iron therapy

Back 10

ferrous salts, most efficiently absorbed

Front 11

parenteral iron therapy

Back 11

iron dextran, iron sucrose complex, iron sodium gluconate complex

Front 12

when is parenteral iron therapy used

Back 12

when pts cannot tolerate oral iron therapy

Front 13

iron dextran

Back 13

IM IV, stable complex

Front 14

iron dextran adv effect

Back 14

anaphylaxis, death

Front 15

iron sucrose, iron sodium gluconate complex

Back 15

less hypersensitivity rxn, IV only. Iron overload tox must monitor iron storage levels

Front 16

acute iron toxicity

Back 16

young children ingest iron tablets, necrotizing gastroenteritis, vomiting, abdominal pain, bloody diarrhea followed by shock, lethargy, dyspnea followed by coma, metabolic acidosis and death

Front 17

treatment of acute iron tox

Back 17

whole bowel irrigation, deferoxamine (iron chelating agent)

Front 18

chronic iron tox

Back 18

iron overload (hemochromatosis), excess iron deposited in the heart, liver, pancreas and may lead to organ failure and death

Front 19

treatment of chronic iron tox

Back 19

intermittent phlebotomy, deferoxamine, deferasirox

Front 20

main source of b12

Back 20

microbial synthesis of meat, poultry, milk, eggs

Front 21

diagnosis of vit b12 deficiency

Back 21

anemia, red tongue, bleeding gums, GI symptoms, neurological symptoms eg numbness or tingling in the feet/hands. Schilling test

Front 22

causes of vit b12 deficiency

Back 22

pernicious anemia, malabsorption syndrome, IBS

Front 23

IM b12

Back 23

cyanocobalamin, hydroxocobalamin

Front 24

signs symptoms of folate deficiency

Back 24

pregnant women give birth to low weight, premature or infants with neural tube defects, anemia, elevated levels of homocyteine

Front 25

causes of folate deficiency

Back 25

pregnancy, hemolytic anemia, celiac disease

Front 26

drugs that cause folate deficiency

Back 26

methotrextae, trimthoprim, pyrimethamine, phenytoin

Front 27

folic acid supplementation

Back 27

does not prevent the neurological damaged caused by vit b12 deficiency

Front 28

folate supplementation may mask

Back 28

vit b12 deficiency and increase prevaence of neurologic disease in elderly populations

Front 29

hematopoietic growth factors

Back 29

glycoprotein hormones that regulate the proliferation and differentiation of hematopoetic progenitor cells in the bone marrow

Front 30

EPO

Back 30

stimulates erythroid proliferation and differentiation by interacting with erythropoieten receptors

Front 31

EPO levels increase

Back 31

in anemia except in anemia of chronic renal failure because EPO is produced in the kidney

Front 32

clinical uses of EPO

Back 32

anemia with chronic renal failure or pts with low levels of EPO

Front 33

adv effects of EPO

Back 33

rapid increase in hematocrit and hemoglobin, hypertension, increased motility and tumor progerssion in cancer pts

Front 34

myeloid growth factors

Back 34

GCSF, gmcsf, rhugmcsf, pegfilgrastim

Front 35

myeloid growth factors MOA

Back 35

stimulate proliferation and differentiation by interacting with specific receptors found on varoius myeloid progenitor cells

Front 36

pegfilgrastim

Back 36

conjugation of filgrastim and PEG, longer serum half life inject once per chemo

Front 37

GCSF, GMCSF

Back 37

cancer chemotherapy induced neutropenia, AML.

Front 38

GCSF most commonly used for

Back 38

mobilization of PBSC

Front 39

adv effects of GCSF

Back 39

bone pain, splenic rupture

Front 40

adv effects of GMCSF

Back 40

high dose related fever, malaise, arthralgias, myalgias and cap leak syndrome

Front 41

IL 11, rIL 11

Back 41

interleukin 11, oprelvekin

Front 42

interleukin and oprevekin funcitons

Back 42

increases the number of peripheral platelets and neutrophils

Front 43

clinical use of IL11, rIL11

Back 43

treatment of thrombocytopenia

Front 44

adv effects of IL11, rIL 11

Back 44

fatigue, headache, dizziness, cardiovascular effects

Front 45

high amounts of tannins or calcium

Back 45

reduce iron absorbtion.