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11 Cards in this Set
- Front
- Back
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How are androgens used to treat anemias?
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They stimulate renal erythropoitin secretion to bump up RBCs
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How are androgens used in post menopausal women?
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The estrogen-androgen combos increase libido. androgen production in the ovaries continues after menopause.
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Why would androgen replacement therapy be beneficial in aging males?
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increases lean body mass, increases hematocrit, and decreases bone turnover.
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Trace the pathway of testosterone synthesis.
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cholesterol, pregnenalone, progesterone, 17a-OH progesterone, androstenedione, testosterone
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What enzyme is responsible for activating testosterone?
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5 alpha reductase, converts to DHT
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What are the adverse effects of anabolic steroids?
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infertility, liver damage, HTN, heart disease risk, endocrine/hematologic changes, acne, prostatic hypertrophy, alopecia, depression, masculinization in females, and feminization/infertility in males.
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How does finasteride work as an anti-androgen?
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It blocks 5 alpha reductase Type 2, which is responsible for 60% of conversion, so it prevents conversion of Testosterone to DHT. Used to treat BPH, alopecia in low doses, but not indicated in women because of potential fetal damage.
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How does leuprolide work as an anti-androgen?
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GnRH analog, suppresses steroidogenesis, use palliatively to treat prostate cancer, and endometriosis(like danazol.) Treats central precocious puberty.
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How does Dutasteride work as an anti-androgen.
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5 alpha reductase Type 1 and Type 2 inhibitor, treats BPH.
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How does spironolactone work as an anti-androgen?
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Competitively inhibits aldosterone, treats HTN, reduces 17 alpha hydroxylase so it lowers plasma testosterone and a-dione. Treats hirsutism in women. SE gynecomastia and hyperkalemia.
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Flutamide, bicalutamide, nilutamide
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orally active antiandrogens used to treat prostate cancer.
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