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13 Cards in this Set
- Front
- Back
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Enanthate
Cypionate Proprionate |
Prepubertal treatment of hypogonadism
Testosterone ester injections Requires 2-3 years of therapy |
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Methyltestosterone
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Postpubertal treatment of hypogonadism
Oral androgen with delayed first-pass For restoration of secondary sex characteristics, potency and libido Side effects: Cholestatic hepatitis, jaundice, hepatic carcinoma, peliosis hepatitis |
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Leuprolide
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Antiandrogen that is a continual dose of GnRH
Produces pharmacological castration |
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Ketoconazole
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Antiandrogen anti-fungal agent that inhibits the p450 enzymes involved in steroid biosynthesis
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Spironolactone
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Antiandrogen aldosterone-antagonist that inhibits androgen biosynthesis
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Finasteride
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5-alpha-reductase inhibitor
Orally active Used for prostate hyperplasia without affecting libido or potency |
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Flutamide
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Androgen receptor antagonist
Used to treat prostate cancer |
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Sildenafil
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Viagra
Oral PDE-V Inhibitor Increases lifetime of cGMP Does not induce erection Take 1 hr. before sex Lasts up to 4 hrs. Metabolized by P450 3A4 pathway Eliminated in bile |
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Side effects of PDE-V Inhibition
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Effects in any tissue other than penis also expressing PDE-V and has cross activity to other PDEs when used at high levels
Disturbs vision via retinal PDE-VI Headache, flushing, nasal congestion, hypotension **CI in pts on nitrates |
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Vardenafil
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Levitra
Oral PDE-V Inhibitor Onset in 15 minutes Lasts 5 hours SE: Reportedly increases QT interval and likelihood for re-entrant arrhythmias |
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Tadalafil
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Cialis
Oral PDE-V Inhibitor Lasts 36 hours Approved for daily use to maintain plasma levels |
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Alprostadil
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PGE1 Agonist
Effective to induce erection Intracavernosal injection or MUSE Stimulates cAMP Lasts 1-3 hours |
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Agents used in combination with PGE1
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Paparavine- nonspecific PDE-I
Phentolamine- nonspecific alpha-adrenergic blocker that maintains vasodilation Also Apomorphine, VIP and Adenosine |
