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24 Cards in this Set
- Front
- Back
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Mast cells are bone marrow-derived CD___+ cells
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34
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NOTE / Remember: some of the symptoms caused by mast cell de-granulation are: flushing, urticaria, diarrhea, abdominal pain, HA, dyspnea, syncope, palpitations
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Regarding mastocytosis, children often do not express ___ mutation
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c-KIT
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Studies have revealed mutations in ___ in many adult-onset cases of mastocytosis
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c-KIT (protooncogene)
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A good reason to try to diagnose the Carney complex (testicular tumors, GH-secreting tumors, Cushing syndrome, lentiginosis and blue nevi, cardiac myxomas, myxoid fibromas, cutaneous myxomas) is early evaluation / treatment of ___
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cardiac myxomas (which are present in 79%)
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NOTE: The Carney complex
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cardiac myxomas (79%)
cutaneous myxomas mammary myxomas lentiginosis / blue nevi Cushing syndrome testicular tumors GH-secreting tumors |
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someone has multiple small skin-colored papules (ears, eyelids, nipples), lentigines, and cardiac myxomas
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Carney complex
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characteristic pigmentation of the medial conjunctiva
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Carney syndrome
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What is LAMB?
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lentigines
atrial myxoma mucocutaneous myxomas blue nevi (part of the Carney complex?) |
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a malignant differential diagnosis for granuloma annulare, rheumatoid nodule, or ganglion cyst; usually on the extremity (hand, wrist)
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epithelioid sarcoma
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most common soft tissue sarcoma of middle and late adulthood; arises from deep tissues
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malignant fibrous histiocytoma (sometimes arise in sites of radiodermatitis or a chronic ulcer)
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negative pre-keratin staining helps to distinguish AFX (atypical fibroxanthoma) from ___
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SCC
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this is a superficial malignant tumor that usually gets an eroded or crusted surface; not BCC or SCC; but does arise in sun-exposed areas in white folks over 50
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AFX (atypical fibroxanthoma) a low-grade malignancy
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pigmented DFSPs, in which the cells contain melanin, predominantly affect persons of color and are called ___
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Bednar tumor
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___ is a marker that distinguishes DFSP from dermatofibroma
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CD34
nestin stromelysin 3 |
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Progressive enlargement beyond 2-3cm in diameter of a dermatofibroma suggests ___
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malignant fibrous histiocytoma or DFSP (2 different cancers)
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what is the other name for dermatofibroma?
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fibrous histiocytoma
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biopsy of acrochordons should be performed in this age group: ___
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children (as they may be the presenting sign of nevoid basal cell carcinoma syndrome)
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NOTE: It is suspected that many dermatofibromas are initiated by injuries to the skin, such as insect bites or trauma
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most commonly on the great toe of middle aged women; overlying toenail becomes brittle and either breaks or is removed, then the tumor mushrooms
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subungual exostosis
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if genital warts are resistant to treatment, consider that they could be ___ (dome-shaped papules on the glans penis)
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pearly penile papules
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multiple fibrous papules should suggest evaluation for diagnosis of ___
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tuberous sclerosis
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Remember: tuberous sclerosis / "epiloia" = epilepsy, low intelligence, adenoma sebaceum, periungual fibromas, shagreen plaques, oral papillomatosis, gingival hyperplasia, ash-leaf macules, skin fibromas, cafe-au-lait spots
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NOTE: hereditary disorders of annular constriction of digits
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Vohwinkel syndrome
mal de Meleda pachyonychia congenita Ehlers-Danlos erythropoietic protoporphyria |
