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36 Cards in this Set
- Front
- Back
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childhood dermatomyositis types
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1. Brunsting: slow, progressive, calcinosis, response to steroids
2. Banker: vasculitis muscles and GI, rapid, severe, steroid unresponsive,high mortlaity |
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childhood DM assoc endocrine
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DM
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childhood DM HLA
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DQA1*0501
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childhood DM and vasculitis. Why?
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TNF-alpha-308a
increased TNF-alpha synthesis increased thrombospondin-1 small vessel occlusion |
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DM adults cytokines
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IL-1alpha, TGF-B, IL-15
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DM drug
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lamisil due to apoptosis
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DM race and sex
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AA women
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linear scleroderma lab
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anti-ssDNA
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scleroderma upregulated
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monocyte chemoattractant protein-1
pumonary and activation-regulated chemokine macrophage infammatory protein-1 IL-8 PDGFB TGFB |
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drug induced morphea
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cathepsin K inhibitor
balicatinb osteoporosis |
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eosinophilic fascitis increase
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IL-5
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NSF proliferating fibroblasts express
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phospho-70-S6 kinase
protein downstream from rapamycin |
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NSF treatment
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most effective optimize renal
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definitive test for Sjogren's
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labial salivary gland biopsy inside lower lip
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Sjogren's Asian patients
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annular dermal plaques on face
no epidermal change |
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fodrin
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major component of membrane cytoskeleton
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Sjogren's
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aquaporin water channel family
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Heberden nodes
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tender hard bony exostoses on dorsolateral DIP
degenerative joint disease |
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interstitial granulomatous dermatitis with arthritis
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symmetrical round to oval erythematous or violaceous plaques on the flanks, axillae, innter thighs, lower abdomen
linear, slightly red or skin olored cords upper back to axillae Arthritis before, with, or after multi joints UE no or mild mucin spon resolve if necessary tx MTX, entanercept, cyclosporine, steroid |
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Palisaded neutrophilic granulomatous dermatitis
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assoc w well-defined CTD (LE or RA)
eroded or ulcerated symmetrical umbilicated papules and nodules on elbows,knuckles, knees BX: LCCV early or palistated granulomatous older |
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Interstitial granulomatous dermatitis reported RA treatment
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enbrel
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MTX induced papular eruption
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RA patients
erythematous inducated papules proimal extremities ` |
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Still's Disease
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not pruritic
trunk and ext before joint pain x mths |
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Still's Disease cytokines
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IL-1B, IL-6, IL-18
S100, S100A8, S100A9, S100A12 |
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Relapsing Polychondritis
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migratory arthralgia
atypical CP Ocular disease mc conjuntivitis, scleritis, or iritis Globe perforation Complete heart block no infiltrate |
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ADULT T-CELL LUEKEMIA LYMPHOMA
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HTLV-1
LAD, HSM, HYPERCALCEMIA, SKIN LESIONS ERYTHEMATOUS PAPULES OR NODULES PRURIGO FLOWER CELLS |
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HTLV-1
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BREAST FEEDING MOTHER TO INFANT
GLUT-1 TRANSPORTER |
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HTLV-1 INFECTS CELL VIA
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GLUT-1 GLUCOSE TRANSPORTER
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INFECTIVE DERMATITIS
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HTLV-1 INFECTION KIDS
CHRONIC ECAEMA OF THE SCALP, AXILLA, GROIN, EXTERNAL AUDITORY CANAL, RETROAURICULAR, EYELID, PARANASAL, ENCK |
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BALAMUTHIA MANDRILLARIS
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AMEBA
CENTRAL FACE TX PENTAMIDINE |
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LYNGBYA MAJUSCULA
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ALAGEA
SEAWEEKD DERMATITIS OFF OF HI AFFECTED AREAS COVERED BY BATHING SUTI DERMAITIS 3- 8 HRS AFTER SWIMMING SHOWER WITHIN 5 MINS TX AS ACUTE BURNS |
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ALCYONIDIUM HIRSUTUM
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DOGGER BANK ITCH
SEAWEED LIKE ANIMAL COLONY NORTH SEA SCOTLAND AND DENMARK |
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ENTEROBIASIS TX
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ALBENDAZOLE,MEBENDAAZOLE, PYRANTEL PAMOATE XONE THEN REPEAT IN 2 WKS
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HOOKWORM
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ANCYLOSTOMA DUODENALE OR NECATOR AMERICANUS
EGGS IN STOOL ALBENDAZOLE, MEBENDAZOLE, PRYANTEL PAMOATE |
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GNATHOSTOMIASIS
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MIGRATORY INTERMITTENT URTICARIA
PAINLES SPEIDOSDES 7 DAYS THEN EVER 2- 6 WKS LARVA MIGRANS PROFUNDUS GNATHOSTOMA DOLOROSI OR PSINGERUM EAT RAW SQUID OR DNAKE RAW FISH EAT LARVA CYST, PENETRATES GASRIC, TX SURGERY AND ALBENDAOZLE,IVERMECTIN |
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FILARIASIS TX
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TOC DEC MICROFILARIAE BUT NOT ADULTS
IVERMECTIN DOXYCYCLIN KILLS INTRACELLULAR SYMBIOTIC BACTERIA WOLFACHIA LONG TERM STERILITY OF ADULT FEMALE WORMS |
