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74 Cards in this Set
- Front
- Back
Centrifugation of whole blood yields:
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an upper layer, a middle layer, and a lower layer.
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The upper layer of centrifuged whole blood is the:
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plasma
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the middle layer of centrifuged whole blood:
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buffycoat, WBC's and platelets
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the bottom layer of centrifuged whole blood:
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red blood cells
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the formed elements of blood are the
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cellular components
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the cellular components of blood consist of
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red blood cells, white blood cells and platelets.
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the fluid portion of blood is the
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plasma
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the percentage of red blood cells of the total blood volume is called the:
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hematocrit
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the normal hematocrit (percentage of red blood cells of total blood volume) is
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45%
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plasma makes up what percent of total blood volume
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55%
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blood volume of the average adult is
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5 liters or 8% of their body weight
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the viscocity of blood is what to water
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4.5 or 5.5 times that of water.
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the ph of blood is
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7.35 to 7.45
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the temperature of blood in teh thorax is
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38 degrees C or 100.4 degrees F (core body temperature)
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What are the major inorganic solute of plasma?
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sodium and chloride
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sodium and chloride contribute to what
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the osmotic pressure of blood
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Plasma proteins make up what percent of plasma
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7-9%
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The albumin plasma proteins are waht percent of total protein.
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60-80%
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the albumin plasma proteins are made in the
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liver
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albumin plasma proteins are important for
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maintaining the osmotic pressure of blood
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the alpha and beta globulins are made in the
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liver
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the alpha and beta globulins transport
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lipids and fat soluble vitamins in the blood
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Gamma globulins are the
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blood antibody fractions
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what is the normal red blood cell count in the male
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5.4 million per cubic millimeter (cmm)
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what is the normal red blood cell count in the female?
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4.8 million per cubic cmm
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what is the higher concentration of red blood cells in the male due to
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testosterone
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testosterone stimulates what
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red bood cell formation
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the cells of red blood cells are
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biconcave discs.
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the red blood cells reasure
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7.5 microns in diameter and 2 microns thick
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Red blood cells lack
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a nucleus adn mitochondria
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red blood cells respire
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anaerobically
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the average life span of a red blood cell
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120 days
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after about 120 days, teh red blood cell is then
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destroyed by the liver, spleen and bone marrow
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function of red blood cell
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to transport oxygen and CO2
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Hemoglobin makes up what percent of fresh wieght (wet weight) of red blood cells
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33-34%
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the normal hemoglobin content of blood is infants is:
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14-20 grams/deciliter (g/100ml)
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the normal hemoglobin content of blood in adult males is
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13-18g/deciliter
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the normal hemoglobin content of blood in females is
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12-16g/dl
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hemolgobin consists of
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red pigment "heme", bound to the protein component globin
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the globin portion is made up of
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two alpha and two beta polypeptide chains
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in a hemoglobin molecule there are
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4 hemes
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the 4 hemes of a hemoglobin molecule each consist of
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a tetrapyrrole (porphyrin) and one iron atome.
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in hemeglobin, iron is in the..
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ferrous state
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in hemoglobin, one molecule of oxygen will
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combine with one iron atom
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per hemoglobin molecules, there will be how many oxygens molecules?
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4
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a single red blood cell contains how many hemoglobin molecules:
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250 million
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a single red blood cell contains how many molecules of oxygen?
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one billion
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methemoglobin is hemoglobin in which
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iron has been oxidized to the ferric form
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iron in the ferric form cannot
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transport oxygen
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a small amount of what is present in red blood cells?
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iron in the ferric form
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drugs that are oxidizing agents can cause an increase in what
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methemoglobin in the red blood cells
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Hematopoises refers to the
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formation of all blood cells
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erythropoisis refers to
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specifically to the formation of red blood cells
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Hyocytoblast is waht kind of cell
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stem cell
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hemocytoblasts are present where
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in red bone marrow
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hemocytoblasts are present in the (specific)
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myeloid tissue
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hemocytoblasts have the potential to form
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any blood cell
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the stem cell transforms into the what
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proerythroblast
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when the stem cell transforms into the proerythroblast, it is commited to
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form an erythrocyte
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From the proerythroblast, the sebsequent stages of the stem cell are
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erythroblast, normoblast, reticulocyte
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during erythropoiesis, the erethroblast and the normoblast do waht
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make hemoglobin.
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the nucleus is lost in the
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late normoblast
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from hemocytoblast to reticulocyte takes how long
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3-5 days
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the reticulocyte is the
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cell type that enters the peripheral circulation
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the reticulocyte matures into
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an erythrocyte in two days after release.
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reticulocyte blood counts are
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an approximation of the rate of red blood cell formation
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Materials needed to make red blood cells include:
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carbohydrates, lipids, amino acids, iron, vitamin B-12, and folic acid.
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what is needed for nucleic acid synthesis?
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two vitamins
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Iron is stored in the liver as
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ferritin or hemosiderin (complexed with proteins)
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What is the blood transport protein for iron?
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transferrin
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What happens when red blood cells lyse at the end of their life span?
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some components of hemoglobin are recycled.
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The fact that red blood cells lyse at the end of their life span and some components of hemoglobin are recycled is true for...
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iron and amino acids that make up the globin portion.
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for iron and amino acids that make up the globin portion, what happens to the heme at the end of the life span?
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the heme is degraded to bilirubin.
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what is bilirubin?
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a yellow pigment that gives color to bile
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