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107 Cards in this Set

  • Front
  • Back
Blood - The only fluid _________ in the body
tissue
Blood - complex __________ tissue
connective
Blood has both ____________components
solid and liquid
living tissue of blood
formed elements
nonliving fluid matrix
plasma
erythrocytes
red blood cells
red blood cells
erythrocytes
function in oxygen transport
formed elements
Leukocytes
White blood cells
cell fragments
platelets
40% of blood volume
formed elements
1% blood volume
White blood cells
55% whole blood
Plasma
Plasma protein that contributes to the osmotic pressure of blood
albumen
Assist in clotting blood
clotting proteins
plasma proteins
defense and transport of lipid proteins
Globulins
Blood taste
metallic
temperature of blood
100.4 - slightly higher than body temp
blood is what % of body weight
8%
how many liters
~6
Formed elements
red blood cells
white blood cells
platelets
Blood volume ___________ in altitude
increases
Biconcave discs
erythrocytes
do erythrocytes have a nucleus?
No
Erythrocytes are full of
hemoglobin
responsible for oxygen transport
hemoglobin
1000:1
ratio of RBC's to White blood cells
how many RBCs in 1 cu mm
~5 million
Which body organ plays the main role in producing blood proteins?
liver
Single RBC contains 250 million
Hemoglobin Molecules
Hemoglobin Molecule
4 mols of Oxygen
Decrease in the oxygen carrying capacity of blood
Anemia
Reduced RBCs or reduced or abnormal hemoglobin production
Anemia
Abnormal hemoglobin
sickle cell anemia
RBCs dam up small blood vessels
sickle cell anemia
Defends body against damage by pathogens
leukocytes
able of move in and out of blood vessels
luekocytes - diapedesis
Able to locate areas of damage via chemical signals
leukocytes - positive chemotaxsis
numbers can be doubled in a few hours
leukocytes
Granule containing WBC's
granulocytes
lobed nuclei
granulocytes
phagocytes of acute infection
neutrophils
responds to allergies and infections or parasitic worms
eosinophils
contain histamine, which attracts other wbcs in an infection area
basophils
granulocytes
neutrophils
eosinophils
basophils
lack granules with normal nuclei
agranulocytes
largest of WBCs
monocytes
macrophages against chronic infections like tuberculosis
monocytes
megakaryocytes
platelets
RBC formation is regulated by
erythropoietin
Hormone that targets bone marrow cells when Oxygen levels are low
erythropoietin
why are leukocytes produced
when a pathogen enters the body
decrease blood flow to the vessel reducing blood loss until clotting can occur
vascular spasms
Platelet plug releases
serotonin
serotonin enhances
vascular spasms
When vascular ___________ is damaged ____________ are exposed and ________ stick to them
endothelium
collagen fibers
platelets
------------- are released to attract more platelets to the site of a cut
chemicals
________ is released by damaged cells
tissue factor
_______ is released and it interacts with tissue factor, vitamin K and calcium to trigger the clotting cascade
PF3
PF3 is released and it interacts with tissue factor, vitamin K and calcium to trigger the ____________
clotting cascade
Thrombin joins ___________ proteins into hairlike molecules called _______
fibrogen
fibrin
Characteristics of RBCs
biconcave
anucleate
hemoglobin
few organelles
Antigens
our immune systems would attack cells with unfamiliar _________ but we tolerate our own
antigens
Blood with and unfamiliar antigen cause antibodies to
agglutinate
Antigens first identified in Rhesus monkeys
Rh blood group
Most americans are Rh
+
If an Rh- person receives Rh+ blood they begin making
antibodies
When does a person reject the wrong Rh blood
after the first blood transfusion
Hemolytic disease of the newborn
it an Rh- woman has two Rh+ babies
fragments of blood cells used for clotting
platelets
Plasma is made mostly of water which
absorbs a lot of metabolic heat
Plasma is made of
water
electrolytes
plasma protein
blood plasma transports over
100 different solutes
what are the most abundant solutes
plasma proteins
plasma proteins are made mostly in the
liver
Plasma Proteins
fibrinogen
albumen
globulin
albumen is responsible for
osmotic pressure of blood
antibodies are types of
globulins
Composition of blood is always
dynamic
Hemoglobin is made of four
amino acid chains
hemoglobin carries
oxygen through the body
Hemoglobin in adults - types and # amino acid chains
two alpha chains and two beta chains
Embryonic hemoglobin
beta chain replaced with gamma chain
In embryonic hemoglobin replacing a beta with a gamma chain produces a
higher grip on oxygen
One iron molecule behind the oxygen molecule
Heme group
Heme group is responsible for
the red color of blood
Horseshoe crab has ________ in hemoglobin which makes it appear blue
copper
blood is heavy because of
iron
diapedesis
WBCs move in and out of blood vessels at will
positive chemotaxis
able to locate areas of damage via chemical signals
when cells are damaged they
call for help
in case of infection WBCs numbers can be
doubled in a few hours
Hematopoiesis
RBC production
Hemocytoblasts
stem cells in bone marrow
Lymphoid stem cells
lymphocytes
Myeloid stem cells
Erythrocytes
Platelets
Basophils
Eosinophils
Neutrophils
Monocytes
Secondary stem cells
Lymphoid stem cells
Myeloid Stem cells
Steps in regulating RBC production
Reduced Oxygen
Kidney releases erythropoietin
binds to receptors in red bone marrow (erythropoiesis)
more RBCs
increased Oxygen
Kidney has sensors for the
oxygen concentration of the blood
Hemostasis
stop bleeding
Hemostasis steps
vascular spasms
formation of platelet plug
coagulation
blood clotting
vascular spasm
slows or stops blood flow to the area
reduces blood flow until clotting
Phagocytes of acute infection
neutrphils
allergies
infections
worms
eosinophils
histamine
attracts WBC
chemotaxis
Basophils
found in lymphatic tissue
immune response
lymphocytes
Chronic infections
Tuberulosis
macrophages
monocytes