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55 Cards in this Set

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Lymphatic system functions (4)

1. To return tissue fluid + proteins back to bloodstream from interstitium


2. To transport products of fat digestion (chylomicrons)


3. To filter bacteria + other harmful substances from body's fluids


4. To manufacture lymphocytes + antibodies

Lymph

Clear/straw-coloured fluid circulating in lymphatic system

Composition of lymph

Similar to blood plasma but lower in protein as larger protein molecules cannot leave blood capillaries

2 places lymph composition undergoes change

1. Small intestine - higher levels of fat (chyle)


2. Liver

Lymphatic vessels begin...

In body tissues as tiny mesh of lymph capillaries, slowly link up as they move toward heart

2 lymphatic ducts lymph vessels will drain into one of

1. Right + left lymphatic ducts


2. Cisterna chyll (thoracic duct)

Lymphatic ducts drain into

Cranial vena cava, near right atrium and return fluid to the heart.

Lymph nodes

Small round structures made up of lymphoid tissue, found interspersed throughout lymphatic system

Lymph node function

Filters lymph that flows through as it returns to bloodstream

Macrophages in lymph nodes function

Remove harmful contaminants from lymph

Lymphocytes

Produced in lymph nodes and are released into lymph

Lymphocytes enter bloodstream when

Lymph drains into cranial vena cava

Lacteal

Projection of lymph vessel where digested fat is absorbed

Thymus gland

Important site for T-lymphocyte maturation

Tonsils are full of

Lymphocytes

The spleen contains

Numerous macrophages

Gut Associated Lymphoid Tissue (GALT)

Found in small intestinal mucosa, also known as Peyer's Patches (aggregated lymphatic nodules)

Movement of materials to lymph vessels occurs by

Hydrostatic pressure and osmosis

Hydrostatic pressure in capillaries compared to interstitial areas

30 mmHg compared to 0

The pressure differential between capillaries and interstitial areas does what

Forced fluids from capillary bed into tissue spaces

What will remain within the capillaries even with pressure difference

Large protein molecules, blood cells and similar materials

Lymph vessels transport

Interstitial fluid to veins of circulatory system

As hydrostatic pressure of blood in capillaries drops, the osmotic effect of retained substances increases until

At venule side of capillary bed it has become half as great as hydrostatic pressure on arterial side

Osmotic pressure does what

Pulls tissue fluids back into bloodstream with dissolved waste products

Hydrostasis and osmosis (6)

1. Pressure differential or capillaries and interstitial areas forces fluids from capillary bed into tissue spaces


2. Large protein molecules, blood cells and similar materials remain within capillaries


3. Hydrostatic pressure of capillary blood drops, osmotic effect of retained substances increases


4. Venule side of capillary bed has become half as great as hydrostatic pressure on arterial side


5. Osmotic pressure pulls tissue fluids back into bloodstream together with dissolved waste products


6. Transference of excess interstitial fluid directly to lymphatic vessels occurs at same time

Sinoatrial node/pacemaker

Electrochemical activator built into cardiac muscle

Parts of hearts electrical conduction system (5)

1. Pacemaker


2. AV node


3. Bundle branches


4. Bundle of His


5. Purkinje fibers

Cardiac electrical impulse (7)

1. Electrical impulse initiated by SA node


2. Impulse spreads out over atria, both contract


3. Depolarizes AV node


4. Conducting fibers (Av bundle or bundle of His)


5. Down right and left bundle branches


6. Bundle of His distributes charge over medial surface of ventricles


7. Contraction of ventricles is stimulated by the Purkinje fibers to the myocardium

ECG

Recording of electrical changes as they accompany the cardiac cycle

P wave

Atrial depolarization — spread of an impulse from SA node through both atria

QRS complex

Atrial depolarization, ventricular depolarization - spread of impulses across ventricles

T wave

Ventricular repolarization

First heart sound (3)

1. Occurs when AV valves close at beginning of ventricular contraction


2. Generated by vibration of blood and ventricular wall


3. Louder, longer, more resonant than second heart sound

Second heart sound (3)

1. Occurs when aortic and pulmonary semilunar valves close at beginning of ventricular dilation


2. Generated by vibration of blood and aorta


3. Aortic valve closes slightly before pulmonary valve

Regulation of heart is affected by

Both sympathetic and parasympathetic stimulation

Cardioacceleratory/pressor centre

A group of neurons within medulla

Stemming from cardioacceleratory/pressor centre (path + innervate)

Sympathetic nerve fibres that travel down a tract in spinal cord and then pass outward in cardiac nerves to innervate SA node, AV node and portions of myocardium

Stimulation of cardioacceleratory centre

Causes nervous impulses to travel along sympathetic fibers. Norepinephrine is released and causes increased HR and strength of contraction

Cardio inhibitory centre is made up of

Parasympathetic fibers (vagus nerve)

Stimulation of cardio inhibitory centre causes

Release of acetylcholine ACh which acts on SA node and AV node, causing decreased HR and strength of contraction

Norepinephrine is what

Catecholamine

Baroreceptors

Nerve cells capable of responding to changes in blood pressure and affect HR

Baroreceptors involved in 3 reflex pathways

1. Carotid sinus reflex (arterial BP)


2. Aortic reflex (arterial BP)


3. Atrial reflex (venous BP)

Carotid sinus reflex (4)

1. Maintains normal BP in brain


2. Baroreceptors in walls of carotid sinus


3. Increase in BP stretches walls - stimulus


4. Decreased HR and strength of contraction -> Decreased cardiac output and arterial pressure

Aortic reflex (2)

1. Baroreceptors in walls of aortic arch


2. Same actions result as carotid sinus reflex

3. Right Heart/Atrial reflex (3)

1. Responds to venous BP


2. Initiated by baroreceptors in caudal vena cava and right atrium


3. When venous BP increases baroreceptors stimulate cardioacceleratory centre

Epinephrine (hormonal control)

Hormone produced by adrenal gland that increases excitability of SA node, and rate + strength of contraction.

Thyroxin (hormonal control)

Released by thyroid gland, increases heart rate.

What is necessary for proper cardiac function?

A proper balance between sodium, calcium and potassium in blood plasma

Calcium

Necesary for contraction of heart muscle. Excess causes increased HR and strength of contraction

Potassium

Interferes with generation of nerve impulses, decreases HR and strength of contraction

Sodium

Interferes with calcium participation in muscle contraction, decreases HR and strength of contraction

Chemoreceptor reflex (3)

1. Stimulated by decreased oxygen and/or pH


2. Stimulated by increased CO2


3. More important in regulating breathing than cardiac function

Proprioceptor reflex

Stimulated by muscle and joint movement, increases heart rate during exercise.

Increased body temp vs decreased

Causes AV node to discharge impulses faster (increased HR) vs. Causes decrease HR and strength of contraction