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63 Cards in this Set

  • Front
  • Back
What is mesenchyme of the head derived from?
Paraxial mesoderm, which becomes segmented into somitomeres and somites

Lateral plate mesoderm

Neural crest ectomesenchyme

Thickenings of ectoderm, or ectodermal placodes
What does the paraxial mesoderm form?
Forms the posterior portions of the cranial base and cranial vault; skeletal muscles of the craniofacial region; dermis, other connective tissues, and the caudal meninges
What does the lateral plate mesoderm form?
Laryngeal cartilages

Other connective tissues of this region
What do neural crest cells form?
Form pharyngeal arch and facial skeletal and other connective tissues in the region

sensory ganglia of cranial nerves V, VII, IX, and X
How many pharyngeal arches develop, and what do they develop as?
6, but the 5th pair is rudimentary.

Develop as bars of mesenchyme separated externally by pharyngeal clefts and internally by pharyngeal pouches
What does the first pharyngeal (mandibular) arch consist of?
A maxillary process on each side, and a mandibular process. The arch joins the frontonasal prominence to form the face around the primitive oral cavity
What is the first pharyngeal arch cartilage and what does it form?
Is Meckel’s cartilage, around which the mandible forms intramembranously

Forms the malleus, incus, and anterior ligament of the malleus of the middle ear; and the sphenomandibular ligament
What parts of the skull are formed from the first pharyngeal arch?
Maxilla, premaxilla, zygomatic bone, and squamous part of the temporal bone
What muscles develop from the first pharyngeal arch?
Muscles of mastication (masseter, temporalis, lateral pterygoid, and medial pterygoid)

Mylohyoid and anterior belly of the digastric

Tensor veli palatini in the soft palate

Tensor tympani in the middle ear
What is the nerve of the first pharyngeal arch and what does it innervate?
Is the trigeminal nerve (CN V)

Innervates muscles that develop from the first arch through its mandibular division (V3)

Provides sensory innervation to the face through its ophthalmic (V1), maxillary (V2), and mandibular (V3) divisions
What is the cartilage of the second pharyngeal arch and what does it give rise to?
Reichert’s cartilage,

Which gives rise to the stapes, styloid process of the temporal bone, stylohyoid ligament, and the lesser horn and upper part of the body of the hyoid bone
What muscles arise from the second pharyngeal arch?
Muscles of facial expression, including the buccinator muscle

Stylohyoid and posterior belly of the digastric

Stapedius
What is the nerve of the second pharyngeal arch and what does it do?
Is the facial nerve (CN VII)

Innervates the muscles that develop from the second arch

Sends its chorda tympani branch to the first arch to carry taste from the anterior 2/3 of the tongue
What does the cartilage of the third pharyngeal arch form?
Cartilage forms the lower part of the body and greater horn of the hyoid bone
What muscle arises from the third pharyngeal arch, and what innervates it?
Gives rise to the stylopharyngeus muscle, which is innervated by the nerve of the third arch, the glossopharyngeal nerve (CN IX)
How are the laryngeal cartilages formed?
The cartilaginous components of the 4th and 6th pharyngeal arches fuse to form the thyroid, cricoid, arytenoid, corniculate, and cuneiform cartilages
What muscles arise from the 4th pharyngeal arch, and what are they innervated by?
Gives rise to muscles of the soft palate (except tensor veli palatini) and pharynx (except stylopharyngeus) innervated by the pharyngeal branch of the vagus nerve (CN X)

Gives rise to the cricothyroid muscle of the larynx innervated by the external laryngeal branch of the vagus nerve
What muscles arise from the 6th pharyngeal arch? And what are they innervated by?
Gives rise to intrinsic muscles of the larynx (except cricothyroid) innervated by the recurrent laryngeal branch of the vagus nerve
How many pharyngeal pouches are there in humans?
There are five pairs in humans, but the fifth pair is atypical and is considered part of the fourth
What is another word for the first pharyngeal pouch?
What does is form?
Is known as the tubotympanic recess and comes into contact with the epithelium of the first pharyngeal cleft (external auditory meatus)

Forms the primitive tympanic (middle ear) cavity and auditory (Eustachian) tube

Contributes to the tympanic membrane (eardrum)
What does the second pharyngeal pouch form?
What does it persist as in adults?
Palatine tonsil, persists as the tonsillar fossa
What does the third pharyngeal pouch form?
Inferior parathyroid glands and the thymus
What does the 4th pharyngeal pouch form?
Superior parathyroid glands

Ultimobranchial body, which gives rise to parafollicular cells of the thyroid which are responsible for secreting calcitonin
What is the one adult structure that forms from the 4 pairs of pharyngeal clefts?

What space does the second pharyngeal cleft temporarily form?
the external auditory meatus

The cervical sinus occurs when the second pharyngeal arch overgrows the third and fourth arches.
Which cleft does the external auditory meatus develop from?
1st
What causes congenital deafness?
If the meatal plug, which closes the external auditory meatus in the fetus from months 3-7, never degenerates
What pharyngeal arches form the auricle?
1st and 2nd
The external ears ascend from what region during development?
Lower neck
What is a lateral cervical cyst?
It is a remnant of the cervical sinus located laterally along the anterior border of the sternocleidomastoid muscle
What does the face develop from?
From five facial primordia—the frontonasal prominence, two maxillary prominences, and two mandibular prominences

Beginning in the fourth week
How is the intermaxillary segment formed and what does it develop into?
The two medial nasal prominences merge to form the intermaxillary segment

It forms the Philtrum of the upper lip,Portion of the maxillary alveolar process carrying the four incisor teeth, Primary palate
What is the premaxilla?
the primary palate and the maxillary alveolar process (carrying incisor teeth)
The medial nasal and maxillary prominences fuse to form what?
the upper lip
The primitive nasal cavity (nasal pit) initially is separated from the oral cavity by what?
the oronasal membrane
The oronasal membrane breaks down at the future site of the _______ to form the primitive ______
incisive canals, choanae
The lower lip is formed by the merging of what?
Mandibular prominences
The secondary palate is formed by the ___ ___ ___, outgrowths from the maxillary prominences that initially are vertically oriented on each side of the tongue
lateral palatal shelves.

These reorient to a horizontal position above the tongue and fuse to form the secondary palate, completing the division of the nasal and oral cavities
What is one mechanism of facial clefts in newborns?
deficient neural crest migration and proliferation, possibly due to high doses of retinoic acid (Vit A)
Cleft lip results from what?
failure of the maxillary and medial nasal prominences to fuse
The anterior 2/3 of the tongue mucosa develops from what?
the first pharyngeal arches (when the lateral lingual swellings overgrow the tuberculum impar)
What does the posterior 1/3 of the tongue mucosa develop from?
The third pharyngeal arch,
(when it overgrows that of the second arches in the copula)
What does the extreme posterior part of the tongue mucosa develop from?
the epiglottic swelling of the fourth arch
What nerve carries GSA fibers from the anterior 2/3 of the tongue?
Mandibular Nerve (V3),

Remember that the anterior 2/3 of the tongue develops from the first pharyngeal arch and therefore is innervated by trigeminal (CNV)
What nerve carries SVA (taste) fibers from the anterior 2/3 of the tongue
Chorda tympani, a branch of the second arch (CNVII)
What nerve carries the SVA and GVA fibers from the posterior 1/3 of the tongue?
Glossopharyngeal (3rd pharyngeal arch).

In its extreme posterior part receives general and some taste sensation from the superior laryngeal branch of the vagus nerve (CN X)
What do tongue muscles develop from, and what are they innervated by?
Tongue muscles develop from myoblasts that migrate from occipital somites,
They are innervated by hypoglossal nerve
what is anklyoglossia?
"Tongue tie". It is insufficient tissue degeneration resulting in a short frenulum extending to the tip of the tongue
Where does the thyroid gland begin development?
The foramen cecum.

The thyroid gland begins as an endodermal proliferation at this site, found between the tuberculum impar and copula.
How can you distinguish a thyroglossal cyst and a branchial cyst?
Thyroglossal cyst, or aberrant thyroid tissue will be located in or near the midline, while branchial or lateral cervical cyst will be on the side of the neck, at the anterior edge of the sternocleidomastoid.
If a pyramidal lobe is present, what muscle is it attached to?
levator glandulae thyroideae
The skull develops from what?
Develops partly from paraxial mesoderm (posterior) and partly from neural crest cells (anterior)
Development of the neurocranium involves what ? (2)
Endochondrol ossification in the cranial base (chondrocranium),

Intramembranous ossification in the cranial vault (desmocranium)
The chondrocranium anterior to the hypophyseal fossa develops from what?
neural crest cells
The chondrocranium posterior to the hypophyseal fossa develops from what?
paraxial mesoderm
What are the cartilages that participate in forming the chondrocranium?
parachordal cartilage

hypophyseal cartilage

trabeculae cranii

ala orbitalis

ala temporalis

periotic capsule
What is scaphocephaly?
A form of craniosynostosis that occurs because the sagittal suture closed prematurely.

Results in a long, narrow skull with frontal and occipital bossing
Trigonocephaly results from the premature fusion of what suture?
metopic suture
What is oxycephaly and what is it a result from?
It is a "tower skull", with abnormally tall skull with a decrease in anteroposterior length. It results from bilateral coronal suture fusion
Plagiocephaly occurs from...
unilateral premature fusion of the coronal or lamboidal sutures
What is occipital plagiocephaly?
unilateral flattening of the occiput due to ipsilateral fusion of the lambdoid suture; the contralateral side of the occiput bulges;
Define faciostenosis
hypoplasia of the middle 1/3 of the facial skeleton, may be associated with the premature fusion of facial sutures;
They have difficulting breathing due to small sinuses and airways, difficulty eating due to malocclusion (mandibular teeth protrude anteriorly), and difficulty speaking/hearing due to a narrow high arched palate
Define hyper/hypotelorism
abnormally wide and narrow separation of the eyes
What genes are linked to craniosynostosis?
mutations in fibroblast growth factor receptors (FGFR2 and FGFR1)