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42 Cards in this Set
- Front
- Back
Cyclic AMP second messenger mechanism for water soluble hormones (6 steps) |
1) Hormone binds receptor 2) Receptor activates G protein 3) G protein activates adenylate cyclase 4) this converts ATP to cAMP 5)cAMP activates Protein Kinases 6) triggers response of target cells |
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first 4 steps of synthesis of thyroid hormone |
1) thyroglobulin synthesizes into follicle lumen 2) Iodide is transported 3) Iodide becomes Iodine 4) Iodine attaches to tyrosine for ming DIT and MIT |
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steps 5-7 of thyroid hormone synthesis |
5) Iodinated tyrosine are linked to form T3 and T4 6) thyroglobulin colloid endocytosed with lysosome 7) lysosome prepares hormones for transport in blood stream |
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effects of PTH (3) |
increased osteoclast activity, reabsorption in kidney tubule, increase absorption from food in intestine |
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Zona Glomerulosa makes |
Aldosterone |
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Zona Fasciculata makes |
Cortisol |
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Zona Reticularis makes |
Androgens |
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Aldosterone effects (3) |
increased Na, decreased K, Raises BP and BV |
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not enough/too much aldosterone |
addison's/Aldosterism |
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effects of cortisol (2) |
gluconeogenesis, lowered immune response |
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too much/not enough cortisol |
Cushing's/Addison's |
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effects of androgen (2) |
Female libido, pubic hair |
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too much/not enough androgen |
masculization of females/unknown |
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glycosuria |
sugar in urine |
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diuresis |
too much urine |
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polyuria |
frequent urination |
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polydipsia |
extreme thirst |
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polyphagia |
hunger |
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lipidemia |
high fat in blood |
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ketouria |
spilling ketones |
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hormones produced by stomach (2) |
gastrin and ghrelin |
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hormones produced by duodenum of SI |
secretin |
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hormones produced by duodenum of LI
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cholecytokinin |
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hormone produced by atria |
atrial natriuretic peptide (ANP) |
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hormone produced by kidney |
erythropoietin (EPO) |
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hormones produced by skin |
cholecalciferol |
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3 types of plasma proteins |
Albumin, globulin, and fibrinogen |
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0-6 days of erythropoiesis |
hematopoietic stem cell, proerythroblast, early erythroblast, late erythroblast, normolast, reticulocyte, erythrocyte |
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two types of leukocytes |
granulocytes and agranulocytes |
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three types of granulocytes and percentages |
neutrophils (50-70) eosinophils (2-4) basophils (.5-1) |
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two types of agranulocytes and percentages |
lymphocytes (25-45) monocytes (3-8) |
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role of neutrophil |
phagocytize bacteria |
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role of eosinophil |
kills parasites, contributes to allerigies |
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role of basophil |
release histamine and heparin |
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role of lymphocytes |
mount immune response by antibodies |
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role of monocytes |
phagocytize, develop into macrophages |
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5 steps of development of platelets |
hematopoietic stem cell, megakaryoblast, pro-megakaryocyte, megakaryocytic, platelet |
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3 steps of hemostasis |
1) vasoconstriction 2) platelet plug 3) coagulation |
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4 clotting factors made in the liver |
2,7,9,10 |
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clotting factor that activates extrinsic pathway |
3 |
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clotting factor that activates intrinsic pathway |
8 |
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4 steps of coagulation |
1) formation of prothrombin activator 2) prothrombin makes thrombin 3) thrombin makes fibrinogen into fibrin 4) clot forms |