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42 Cards in this Set

  • Front
  • Back

Cyclic AMP second messenger mechanism for water soluble hormones (6 steps)

1) Hormone binds receptor 2) Receptor activates G protein 3) G protein activates adenylate cyclase 4) this converts ATP to cAMP 5)cAMP activates Protein Kinases 6) triggers response of target cells

first 4 steps of synthesis of thyroid hormone

1) thyroglobulin synthesizes into follicle lumen 2) Iodide is transported 3) Iodide becomes Iodine 4) Iodine attaches to tyrosine for ming DIT and MIT

steps 5-7 of thyroid hormone synthesis

5) Iodinated tyrosine are linked to form T3 and T4 6) thyroglobulin colloid endocytosed with lysosome 7) lysosome prepares hormones for transport in blood stream

effects of PTH (3)

increased osteoclast activity, reabsorption in kidney tubule, increase absorption from food in intestine

Zona Glomerulosa makes

Aldosterone

Zona Fasciculata makes

Cortisol

Zona Reticularis makes

Androgens

Aldosterone effects (3)

increased Na, decreased K, Raises BP and BV

not enough/too much aldosterone

addison's/Aldosterism

effects of cortisol (2)

gluconeogenesis, lowered immune response

too much/not enough cortisol

Cushing's/Addison's

effects of androgen (2)

Female libido, pubic hair

too much/not enough androgen

masculization of females/unknown

glycosuria

sugar in urine

diuresis

too much urine

polyuria

frequent urination

polydipsia

extreme thirst

polyphagia

hunger

lipidemia

high fat in blood

ketouria

spilling ketones

hormones produced by stomach (2)

gastrin and ghrelin

hormones produced by duodenum of SI

secretin

hormones produced by duodenum of LI

cholecytokinin

hormone produced by atria

atrial natriuretic peptide (ANP)

hormone produced by kidney

erythropoietin (EPO)

hormones produced by skin

cholecalciferol

3 types of plasma proteins

Albumin, globulin, and fibrinogen

0-6 days of erythropoiesis

hematopoietic stem cell, proerythroblast, early erythroblast, late erythroblast, normolast, reticulocyte, erythrocyte

two types of leukocytes

granulocytes and agranulocytes

three types of granulocytes and percentages

neutrophils (50-70) eosinophils (2-4) basophils (.5-1)

two types of agranulocytes and percentages

lymphocytes (25-45) monocytes (3-8)

role of neutrophil

phagocytize bacteria

role of eosinophil

kills parasites, contributes to allerigies

role of basophil

release histamine and heparin

role of lymphocytes

mount immune response by antibodies

role of monocytes

phagocytize, develop into macrophages

5 steps of development of platelets

hematopoietic stem cell, megakaryoblast, pro-megakaryocyte, megakaryocytic, platelet

3 steps of hemostasis

1) vasoconstriction 2) platelet plug 3) coagulation

4 clotting factors made in the liver

2,7,9,10

clotting factor that activates extrinsic pathway

3

clotting factor that activates intrinsic pathway

8

4 steps of coagulation

1) formation of prothrombin activator 2) prothrombin makes thrombin 3) thrombin makes fibrinogen into fibrin 4) clot forms