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11 Cards in this Set
- Front
- Back
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Which interaction is the major driving force of protein interactions/folding?
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Hydrophobic interactions
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What is the order of strength of bonds seen in cells?
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Covalent > ionic > H bonds > van der Waals attractions
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Give an instance of covalent bonding in protein folding. Under what conditions must this occur?
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Disulfide bonds formed between cysteine a.a.'s. Formed under oxidizing conditions.
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Where would you see disulfide bridges forming?
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In the secretory pathway (i.e.: ER, golgi, endosomes, lysosomes, extracellular space, etc.)
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Where won't you see disulfide bridges in proteins?
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In the cytosol, the nucleus or mitochondria.
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What designates the formation of secondary structures of amino acids?
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H-bonds.
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What drives the formation of tertiary structures in proteins? Where, specifically?
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Hydrophobic interactions between the side chains (R chains).
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Define a domain.
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A self-contained folded unit of a polypeptide.
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Most polypeptides are ____ to ____ amino acids long.
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100-800
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What is the weight range of the average polypeptide?
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12 to 90kDa of molecular weight.
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Native states can be in equilibrium with near-native states (ie. molten globules). True or False?
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True.
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