Anaphylaxis

Front 1

Mechanism of allergic reaction

Back 1

Type 1 hypersensitivity

Front 2

Clinical Signs of Allergic Reaction

Back 2

Urticaria
Angioedema
Pruritis
May be biphasic c symptoms 4-8 hrs later
Stridor, dyspnea, wheeze

Front 3

Anaphylaxis

Back 3

Allergic reaction + respiratory compromise or cadiovascular collapse

Front 4

Respiratory Treatment

Back 4

1. Intubation-early in course
2. Give O2
3. Nebulized Albuterol 0.5 mL of 5% solution in 3mL saline

Front 5

Epinephrine

Back 5

Moderate Reaction: Epi 0.3-0.5 mL of 1:1000 q 5-10 min. May Repeat. If no response, begin IV therapy


Use for severe respiratoy distress, edema, laryngospasm or shock

0.1 mL of 1:1000 epi in 10 mL saline and infuse over 5-10 min.
If no response start infusion of 1mL of 1:1000 in 500 mL saline at 0.5-2 mL/min

Front 6

Antihistamines

Back 6

Diphenhydramine 25-50 mg IV

Ranitidine 50 mg

Front 7

Steroids

Back 7

Control delayed response

Prednisone 60 mg PO
Severe cases: Methylprednisone 125 mg IV

Front 8

Observation

Back 8

Mild: 1 hr in ED
Needed Epi: 6 hrs in ED
Severe reaction: ICU

Front 9

Discharge from ED

Back 9

Consider giving Epi-Pen
Treat c antihistamine and pred X 4 days