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13 Cards in this Set
- Front
- Back
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Non narcotic analgesic |
Para-aminophenol derivatives NSAIDs |
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Para-aminophenol derivatives |
Phenacetin - nephrotoxic paracetamol - hepatotoxic |
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1st line analgesic for OA |
Paracetamol |
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SE of paracetamol |
Mild transaminitis SJS-TEN |
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Toxicity of paracetamol |
> / = 150 mg/kg /day |
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Risk factors for paracetamol hepatotoxicity |
Dose >/= 150 mg/kg/day Pre-existing liver disease Concomitant use of enzyme inducer (CYP1A2) |
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NSAIDs Non selective |
Aspirin and salicylates Pyrazole Indole Pyrrole Phenylaceric acid Fenamates Oxicams Propionic acid |
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Natural sources of narcotics |
Opium: P. somniferum P. bracteatum |
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MOA of narcotics |
Stimulate the release and mimic the action of endogenous opioid peptides |
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endogenous opioid peptides |
Endorphins, endomorphin, enkephalins, dynorphins |
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Narcotic receptors |
Mu, kappa, delta |
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Effects of narcotics |
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Clinical uses of narcotics |
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