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3 Cards in this Set
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Effects of anaesthesia on renal function |
Direct nephrotoxicity Indirect - hypotension, ADH release, Aldosterone activation, prostaglandin release changes (autoregulation of renal perfusion) |
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What drugs have nephrotoxic effects |
compound A - sevofluorane flouride ions Hypotension |
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How does renal disease affect anaesthesia |
Metabolic acidosis - decreased renal exc, increased active fraction of weak acids, myocardial dysfunction Hypoprotenaemia - more free drug Uraemia - more free drug |
