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59 Cards in this Set
- Front
- Back
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What dx results from poor dental hygeine?
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gingvitis
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What dx results from poor dental hygeine?
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gingvitis
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What dx results from poor dental hygeine?
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gingvitis
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What are the risk factors for intra-abd inf?
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sx or trauma
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What is the risk factor for pulmonary inf?
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aspiration of oral flora
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What are the risk factors for pelvic inf?
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GYN sx or malignancy
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What are the risk factors for brain abscess?
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sinus or ear inf, spread of mandibular inf
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What are the risk factors for intra-abd inf?
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sx or trauma
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What are the risk factors for intra-abd inf?
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sx or trauma
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What are the rick factors for soft tissue inf?
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trauma or tissue damage
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What is the risk factor for pulmonary inf?
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aspiration of oral flora
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What is the risk factor for pulmonary inf?
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aspiration of oral flora
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What anaerobic bacteria is g+ spore-forming rod?
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Clostridium
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What are the risk factors for pelvic inf?
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GYN sx or malignancy
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What are the characteristics of fusobacterium?
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anaerobic g- rod, NF of gut
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What are the risk factors for pelvic inf?
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GYN sx or malignancy
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What are the risk factors for brain abscess?
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sinus or ear inf, spread of mandibular inf
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What bacterial inf causes fasciitis, gas production felt as crepitant, and requires extensive debridement/amputation?
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C. perfringens soft tissues inf
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What are the risk factors for brain abscess?
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sinus or ear inf, spread of mandibular inf
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What are the rick factors for soft tissue inf?
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trauma or tissue damage
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Describe C. perfringens alpha toxin pathogenesis
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is a lecithinase that damages cell mem
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What are the rick factors for soft tissue inf?
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trauma or tissue damage
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What anaerobic bacteria is g+ spore-forming rod?
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Clostridium
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What anaerobic bacteria is g+ spore-forming rod?
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Clostridium
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What are the characteristics of fusobacterium?
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anaerobic g- rod, NF of gut
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What are the characteristics of fusobacterium?
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anaerobic g- rod, NF of gut
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What bacterial inf causes fasciitis, gas production felt as crepitant, and requires extensive debridement/amputation?
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C. perfringens soft tissues inf
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Describe C. perfringens alpha toxin pathogenesis
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is a lecithinase that damages cell mem
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What bacterial inf causes fasciitis, gas production felt as crepitant, and requires extensive debridement/amputation?
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C. perfringens soft tissues inf
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Describe C. perfringens alpha toxin pathogenesis
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is a lecithinase that damages cell mem
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What anaerobic bacteria causes food poisoning?
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C. perfringens
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Describe pathogenesis of C. perfringens toxin that causes food poisoning
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enterotoxin that causes nausea, cramps, diarrhea 12-24hrs after ingestion
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What is the source of C. perfringens?
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soil and GI
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Describe mechanism of C. botulinum toxin
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heat labile neruotoxin that is absorbed in gut, enters bld, and taken up by axons, blocks SNAP25, synaptobrevin, or synactin which interferes w/ neurovesicle fusing w/ synaptic mem, B binds cholinergic nerves, A prevents release of acetylcholine
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What bacteria produces very potent toxin that can be used as bioweapon?
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C. botulinum
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What bacteria causes flaccid paralysis?
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C. botulinum
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What are 3 types of botulism?
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foodborne (home canning), infant (honey), wound (rare)
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What is the source of C. botulinum?
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soil and water
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What is the source of C. tetani?
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soil and GI
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What bacteria has a terminal spore?
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C. tetani
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What bacteria is problem in developing countries – neonate inf of unbilical cord contaminated w/ dirt?
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C. tetani
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What is mechanism of C. tetani toxin?
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1. A enters CNS by retrograde tport – released from postsynaptic dendrites across synaptic cleft and enters presynaptic terminals
2. Breaks down synaptobrovin that blocks release of inhibitory neurotmitters (GABA) -> unregulated excitation -> spastic paralysis |
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What bacteria causes spastic paralysis?
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C. tetani
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What is the source of C. difficile?
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NF of GI
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What bacteria causes many nosocomial inf?
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C. diff
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What bacteria causes antibiotic-dependent GI dx and describe it?
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C. diff, mild diarrhea to pseudomem formation
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Describe toxin A of C. diff
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a. Enterotoxin – hypersecretion of fluid
b. Attracts neutrophils c. Induces cytokine secretion |
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Describe toxin B of C. diff
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a. Depolymerization of actin
b. Loss of cell adhesion c. Death of gut epi cells |
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Describe pathogensis of C. diff
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1. Spores ingested (found in hospitals)
2. Antibiotics dec NF 3. Spores germinate – release toxins 4. Cell death and inflm and fibrosis, pseudomem formation |
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What are the characteristics of poststrep?
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g+ cocci
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What is the source of Poststrep?
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NF of mouth and colon
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What bacteria commonly causes polymicrobial inf w. Bacteroides?
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Poststrep
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Describe Actinomyces
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g+ aerotolerant anaerobe, filamentous
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What is the source of Actinomyces?
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oral NF
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What bacteria has macroscopic colonies that can be seen in lesions (Sulfur granules) - granulomatous?
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Actinomyce
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What is source of Propionibacterium?
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skin and GI
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Describe Bacteroides
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Strictly anaerobic g- rod, w/o endotoxin
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How is Bacteroides successful at abscess formation?
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Capsular polysaccharide complex – allows abscess formation specifically by polysaccharide A which attracts CD4 leading to inflm
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What anaerobe causes opportunistic inf and has high antibiotic resistance?
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Bacteroides fragilis
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