Alzheimers And Migraine Drugs

Front 1

Ergotamine

Back 1

Ergot alkaloid with a.a. side chain
Partial agonist of alpha adrenoceptors
Increases BP (vasoconstriction)
Partial antagonist of 5HT1

Front 2

Dihydroergotamine

Back 2

Ergot alkaloid with a.a. side chain
Partial antag. of alpha adrenoceptors
Antagonist and partial agonist of 5HT1
Safer than ergotamine because doesn't produce peripheral vasoconstrictor effects

Front 3

Bromocriptine

Back 3

Ergot alkaloid with a.a. side chain
Agonist of DA receptors

Front 4

Methysergide

Back 4

Ergot alkaloid with amine side chain
Antagonist of 5HT2 receptors
Used for migraine prophylaxis

Front 5

Sumatriptan

Back 5

5-HT1 agonist
Subq dose has rapid onset (10min) and relieves accompanying symptoms
Oral dose gives relief in 1.5-2hr.
Not recommended for patients with ischemic heart disease
Short plasma T1/2 so headaches often recurr
Take when symptoms start not at aura

Front 6

Naratriptan

Back 6

5-HT1 receptor agonists
Higher bioavailability than oral sumatriptan and longer T1/2
Fewer recurrent HAs
Tablet form

Front 7

Rizatriptan

Back 7

Higher oral bioavailability than sumatriptan like Naratriptan
Has been shown to improve migraine-specific quality of life indices
Fast onset (30 min)
Tablet form can be dissolved on tongue

Front 8

Zolmitriptan

Back 8

Better oral availability than sumatriptan
Proven best reliever of menstrual migraines
Tablet Form

Front 9

Treximet

Back 9

Sumatriptan/Naproxen combo
Constricts basilar artery and dura vasculature
Inhibits synthesis of inflammatory mediators

Front 10

Tacrine

Back 10

First ACHE Inhibitor
Assoc with hepatotoxicity and has to be given 4x/day
Rarely used

Front 11

Donepezil

Back 11

Cholinesterase Inhibitor for Mild-Mod/Sev Alz
1x/day regimen
SIde effects of cholinergic overstimulation
Selective for "acetyl" cholinesterase

Front 12

Rivastigmine

Back 12

Cholinesterase Inhibitor for mild- mod/sev Alz
Inhibits "acetyl" and "butyryl" cholinesterase

Front 13

Galantamine

Back 13

Cholinesterase Inhibitor
Activates central nicotinic receptors

Front 14

Memantine

Back 14

NMDA receptor antagonist that decreases Glutamate excitotoxicity of neurons
Use in Mod-Sev Alz in combo with CHE Inhibitor

Front 15

Dimebon

Back 15

Antihistamine used in Russia
Supposedly blocks toxic actions of Beta amyloid and modulates NMDA receptors through inhibiting Ca channels