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10 Cards in this Set
- Front
- Back
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ADR Categories |
Predictable (Type A) Unpredictable (Type B) |
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Type A Reaction |
Dose-dependent reaction, most common |
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Type B Reaction |
Not dose-dependent, unrelated to pharmacologic actions of drug -Influenced by pt-specific susceptibility factors -Drug allergies, pseudoallergic reaction, drug intolerances and idiosyncratic reactions |
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Types of Drug Allergy |
4 Types -I: Immediate, IgE-mediated immune response -II: Minutes-hrs after exposure -III: 3-10 hrs after exposure; Immune-complex reactions -IV: >48 hrs-weeks after exposure; delayed hypersensitivity reactions |
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Drugs Commonly Associated with Photosensitivity |
Carbamazepine Diuretics MTX PO & Topical Retinoids Quinolones St. Johns Wort Sulfa Abx Tacrolimus Tetracyclines Voriconazole |
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Drugs Commonly Associated w/ TTP |
Clopidogrel Ticlodipine |
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Drugs Associated w/ Severe Skin Reactions |
Allopurinol, Lamotrigine, Penicillins, Phenytoin, Piroxicam, Sulfamethoxazole |
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Medications that contain egg |
Clevidipine (Cleviprex), propofol (Diprivan), Yellow Fever vaccine Influenza vaccine (if hives occur, can rechallenge..use flublok if true reaction occurs) |
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Medications that contain soy/peanut |
Clevidipine (Cleviprex), propofol (Diprivan), progesterone (Prometrium capsules) |
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T/F: Patients should be re-challenged/desensitized with an agent that's caused SJS or TEN |
False |
