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12 Cards in this Set
- Front
- Back
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Solar lentigo
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Pigmented keratinocytes
Dark brown to black macules which develop in sun-exposed areas. Lesions may increase in size over the years. Increase with age. Benign |
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Seborrheic keratosis
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Common, often multiple, benign tumors which usually first appear in middle life.
Affect any part of the body, except plams and soles. Eruptive form is associated with internal malignancies (Lesser-Trelat sign). Horn cyst Benign |
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Basal cell carcinoma
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The most common cutaneous malignant neoplasm
Affects mostly sun-exposed areas of the skin. Nodular BCC -most common Sclerosing or morpheaform BCC -spiky histology Superficial BCC Fibroepithelioma of Pinkus Never metastasizes but is very destructive Histology: blue islands of cells cleft |
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Actinic keratosis
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Precursor to SCC
Feels like sandpaper Atypical keratinocytes only affect basal layer |
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Carcinoma in-situ (Bowen's disease)
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Thickness of epidermis is abnormal
Parakaratosis Retained nuclei in s. corneum Bizarre looking |
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Invasive squamous cell carcinoma
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Abnormal keratinocytes
Invades dermis |
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Keratoacanthoma
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Relative of SCC?
Explosive growth Firm indurated papular nodule with frequent crater Pink looking Keratinocytic |
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Melanocytic lesions
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Nevi (benign)
-Junctional nevus: melanocytes just at basal layer -Compound nevus: melanocytes at basal layer and in dermis -Intradermal nevus: melanocytes in the dermis Melanomas (malignant). |
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Melanocytes
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Round nuclei with bubbles
Pink cytoplasm |
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Congenital nevi
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Small
-less than 1.5 cm -no risk of melanoma Medium -1.5-19.9 cm -no risk of melanoma Large -greater than 20cm -risk of melanoma -risk of neural involvement Melanocytes wrap around hair follicles |
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Melanoma clinical features and histological features
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Flat lesions with irregular borders and color variegation.
Most commonly on the face and neck but they can affect any area of the body. Asymmetrical lesions. Variation in the size and shape of the nests. Poor circumscription. Predominance of single melanocytes and presence of pagetoid melanocytes above the dermal-epidermal junction |
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Metastatic melanoma
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Solitary lesion in dermis
No connection to epidermis |
