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13 Cards in this Set
- Front
- Back
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Bilirubin
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RBC gets engulfed and broken down by a phagocyte
Hemoglobin molecule gets broken down The globular proteins are broken down into amino acids which get recycled Each heme unit loses its iron and is converted to biliverdin Biliverdin is converted into biliruibn Bilirubin is excreted in bile and kidneys iron is transported by transferrin and goes back to the liver |
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Macrophages
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in spleen, liver, and bone marrow
Break down RBCs Bilirubin goes into the liver and then small intestines or kidneys |
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Negative feedback regulation of erythropoiesis
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get pic
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Anemia
Causes |
Dietary deficiency of iron, B12 or folic acid
red bone marrow failure - like from chemotherapy Epo - cloning and biogenetics Destructionof red blood cells |
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Formation of RBCs
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Erythropoietin (Epo) stimulates formation of erythroblasts which forms red blood cells
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Platelet Formation
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Progenitor cells form megakaryocytes
Megakaryocytes burst and the fragments are platelets Platelets are impiortant in clotting |
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WBC Formation
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Stem cells for the formation of WBCs originate in the bone marrow
Myeloid stem cells create progenitor cells which give rise to all formed elements except lymphocytes One type of progenitor cells produce mature RBCs; a second type produces platelets; a thrid type produce neutrophils, eosinophils, basophils, and monocytes Granulocytes complete their development in the bone marrow |
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Formation of Granulocytes
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Myeloblasts
Myelocyte Band cell Mature leukocyte |
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Formation of monocytes
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Begin differentiation in the bone marrow
enter the bloodstream Complete development when they become free macrophages in the periopheral tissues |
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Lymphocytes
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produced in the bone marrow, thymus, spleen, and lymph nodes
Lymphocytes from stem cells in the bone marrow become b cells or natural killer cells Lymphoid stem cells migrating to the thymus mature into T cells |
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Lymphocytes
B cells |
B cells produce antibodies
Cause antibody-antigen reactions |
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Lymphocytes
T cells |
t cells migrate to the peripheral tissues
Take part in cell-mediated immunity |
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Lymphocytes
Natural Killer Cells |
NK cells
formed from stem cells in the bone marrow - like B cells Involved in immunologic surveillance |
