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10 Cards in this Set
- Front
- Back
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Blood Clotting
Phase I |
Vasoconstriction
Close down blood vessels so you don't lose blood release of serotonin and thromboxane A2 stimulate vasoconstriction |
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Blood Clotting
Phase II |
Platelet plug formation
Endothelium lining blood vessels is disrupted and expose wall of blood vessel (collagen is exposed) Vessel wall is sticky and platelets adhere (stick) to it Positive feedback loop As platelets stick, they release factors (ADP and thromboxane A2) that increase stickiness and lead to secondary aggregation which then forms the platelet plug Release of ADP and thromboxane is called release reaction |
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Blood Clotting
Phase II - Release Reaction |
In order to undergo a release reaction, the production of prostaglandins by the platelets is required
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Blood Clotting
Phase III |
Clotting Phase
Clot formation Formation of fibrin Fibrinogen is converted to fibrin 2 Pathways - intrinsic and extrinsic pathway |
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Intrinsic Pathway
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Produces clots from blood left in a test tube or in a damaged blood vessel when collagen is exposed to plasma
Inherent - automatically makes clot Slower than extrinsic pathway Occurs without addition of any additional chemicals |
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Extrinsic Pathway
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Damaged tissues release a chemical that initiates a shortcut in clotting
Tissues release thromboplatin from damaged cells Occurs in tissues, not blood vessels Less steps and quicker than intrinsic pathway |
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Common Pathway
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Both extrinsic and intrinsic pathway get to step that both paths need to take part in - Common Pathway
Starts with Factor X Converts prothrombin to thrombin which then converts fibrinogen to fibrin See pic pg. 2 Prothrombinase is enzymed needed to convert prothrombin to thrombin |
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Blood clot
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Composed of platelets, fibrin, and trapped red blood cells
Contraction of platelets is clot retraction - forms a more effective plug Fluid squeezed from the clot as it retracts is serum - plasma without fibrinogen |
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Factor XIII
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Stabilizing protein that helps to solidify clot
Assures bleeding won't happen |
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Aspirin
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Aspirin inhibits the formation of prostaglandins and therefore inhibits the release reaction by platelets
Excessive amount sof aspirin can increase bleeding time Bad in blood donors and women ready to give birth Good in people who have atherosclerosis |
