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70 Cards in this Set
- Front
- Back
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Phenytoin
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Dilantin
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Carbamazepine
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Tegretol
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Ezogabine
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Potiga
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Gabapentin
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Neurontin, Gabarone
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Tiagabine
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Gabitril
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Oxcarbazepine
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Trileptal
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Pregabalin
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Lyrica
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Lacosamide
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Vimpat
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Vigabatrin
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Sabril
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Valproate
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Depakote
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Lamotrigine
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Lamictal
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Topiramate
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Topamax
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Felbamate
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Felbatol
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Zonisamide
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Zonegran
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Leviteracetam
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Keppra
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Rufinamide
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Banzel
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Infantile spasms drug?
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Vigabatrin
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Absence seizure drug?
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Ethosuximide
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Ethosuximide
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Zarontin
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Broad Spectrum Inducers
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Carbamazepine
Phenytoin Phenobarbital |
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AEDs that inhibit enzymes:
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VPA (CYP2C19, UGT)
Felbamate (2C19) Topiramate (2C19) Oxcarbazepine (2C19) |
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Selective 3A4 Inducers
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Felbamate
Topiramate Oxcarbazepine |
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CBZ rash genes?
(higher risk for Steven's Johnson rash) |
HLA-B 1502
HLA-A 3101 |
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Clobazam
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Onfi
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Fosphenytoin
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Cerebyx
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Primidone
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Myosine (sp?)
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Gabapentin PK
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saturable absorption (L amino acid transporter)
erratic absorption no PK interactions renal elim (test CrCl) |
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Gabapentin AE
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Weight gain
dizzy blurry vision solmnence edema |
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Gabapentin indication
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partial and
2nd generalized seizures |
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Pregabalin PK
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linear absorption (doesn't use lamino transporter)
no PK interactions renal elim (test CrCl) |
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Pregabalin AE (worse than Gabapentin)
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Weight gain
dizzy solmnence blurry vision edema euphoria in some pt |
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Pregabalin indication
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partial seizure
2nd generalized seizures |
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Lamotrigine
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complete absorption
hepatic metabolism glucuronidation (UGT1A4) -very susceptible to other inducers or inhibitors |
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Lamotrigine metabolism is induced by:
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Oral contraceptive during active pill!
doubles clearance of lamotrigine |
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Lamotrigine AE
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mild sedation
weight neutral rash! Steven's Johnson and TEN |
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Lamotrigine rash risk factors:
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High initial dose or fast titration
Concominant VPA (inhibitor) Children Rash w/ other AED No clear genetic link |
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Lamotrigine MOA
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Na channel/suppresses rapid firing neurons
Inhibits VG Ca channels Decreases synaptic glutamate release |
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Topiramate indication
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generalized seizures
migraine |
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Topiramate interactions
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inhibits 2C19
induces 3A4 (dose dependent) |
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Topiramate AE
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Profound cognitive effects
"STUN" word finding difficulties kidney stones (dehydration risk) weight loss |
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Levetiracetam MOA
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binds to SV2A
modulates NT release Unique MOA |
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Levetiracetam PK
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Renal elim (CrCl)
no drug interactions! start at maintenance dose |
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Levetiracetam AE
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Sleepiness (goes away after a week or so)
behavioral issues psychosis. (pre existing mental issues, bad!) no rash weight neutral |
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Oxcarbazepine MOA
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blocks Na channels
stops high frequency firing |
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Oxcarbazepine interactions
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less inducing than carbamazepine.
Induces CYP3A4 Inhibits CYP2C19 |
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Oxcarbazepine PK
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long half life/BID dosing
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Oxcarbazepine AE
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more than in carbamazepine.
more hyponatremia! kids tolerate this well |
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Lacosamide PK
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Renal elim (test ClCr)
weight neutral |
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Vigabtrin MOA
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decrease GABA metabolism
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Vigabatrin indication
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Infantile spasms
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Vigabatrin AE
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peripheral vision loss in 30% of patients.
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Ezogabine MOA
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K channel opener
Unique MOA |
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Ezogabine AE
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Urinary retention
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Ezogabine metabolized by
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glucuronidation
acetylation can be induced |
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Bromocriptine
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Parlodel
dopamine agonist Parkinsons |
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Ropinirole
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requip
dopamine agonist Parkinsons |
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Pramipexole
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Mirapex
dopamine agonist Parkinsons |
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Rotigatine patch
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Neupro
dopamine agonist Parkinsons |
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Levodopa/Carbidopa
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Sinemet
Parkinsons psychosis, hallucinations |
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Amantadine
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Symmetrel
renal elim (test CrCl) confusion (don't use in old peeps!) |
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Selegiline
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Emsam
MAO-B inhibitor |
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Selegiline ODT
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Zelapar
MAO-B inhibitor |
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Rasagiline
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Azilect
MAO-B inhibitor |
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Entacapone
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Comtan
Levodopa sparing effect Doesn't cross BBB |
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Tolcapone
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Tasmar
Levodopa sparing effect Admin w/ Sinemet Crosses BBB increases "on time" Unique MOA |
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Apomorphine
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Apokyn
works in 10 min for about an hour. must pre treat w anti nausea dopamine agonist |
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Donezepil
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Aricept
AChE inhibitor Alzheimers titrate 4 weeks |
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Rivastigmine
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Exelon
AChE inhibitor dual MOA (ache, buchE) Alzheimers titrate 4 weeks |
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Galantamine
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Razadyne
AChE inhibitor adjust for liver and renal disease Alzeimers titrate 4 weeks |
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Memantine
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Namenda
Alzheimers |
