Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
39 Cards in this Set
- Front
- Back
|
Carbamazepine
|
Tegretol (PO)
-200mg BID -2400mg |
|
|
Gabapentin
|
Neurontin (PO)
-300mg TID -4800mg |
|
|
Lamotrigine
|
Lamictal (PO)
-25mg QOD if on VPA (25-50mg if not) -100-150mg if on VPA (500mg if not) |
|
|
Oxcarbazepine
|
Trileptal (PO)
-300mg BID -3000mg |
|
|
Phenobarbital
|
Dilantin (PO, IV, IM)
-1-3mg/kg/day -300mg |
|
|
Phenytoin
|
Dilantin (PO, IV)
-3-5mg/kg/day (200-400mg) -600mg |
|
|
Topiramate
|
Topamax (PO)
-25-50mg/day -1000mg |
|
|
Valproic Acid
|
Depakote (PO, IV)
-15mg/kg (500-1000mg) -60mg/kg (5000mg) |
|
|
Lacosamide
|
Vimpat (PO, IV)
-50mg BID -400mg |
|
|
Felbamate
|
Felbatol (PO)
-1200mg -3600mg |
|
|
Pregabalin
|
Lyrica (PO)
-150mg -600mg |
|
|
Levatiracetam
|
Keppra (PO, IV)
-500mg BID -4000mg |
|
|
Tiagibine
|
Gabitril (PO)
-4-8mg/day -80mg |
|
|
Zonisamide
|
Zonegran (PO)
-100-200mg -600mg |
|
|
Traditional AEDs
|
Phenobarbital
Primidone Phenytoin Ethosuximide Carbamazepine Valproate |
|
|
Common Dose Related Adverse Effects
|
Coordination Problems
Diplopia Dizziness/lightheadedness Sedation Unsteady gait |
|
|
Which AEDs may cause the life threatening adverse effect of CV issues including arrhythmia?
|
Carbamazpeine
Phenytoin |
|
|
Which AEDs have the potential to cause aplastic anemia?
|
Felbamate
Zonisamide Valproate Carbamazepine |
|
|
What AED has the potential to cause agranulocytosis?
|
Carbamazepine
|
|
|
Which AEDs have dermatological SEs including Stevens Johnson syndrome?
|
Valproate
Gabapentin Pregabalin Levetiracetam Topiramate |
|
|
AED general drug related adverse effects
|
Behavioral/Personality changes
Cognitive Dermatological Slowed movements Weight gain |
|
|
AEDs that have hepatic ADEs (fuliminant hepatitis and hepatic necrosis)
|
Valproate
Felbamate Lamotrigine Phenobarbital |
|
|
AEDs that may lead to hyponatremia
|
Carbamazepine
Oxcarbazepine |
|
|
AEDs that interfere with Vitamin D metabolism (older AEDs)
|
Carbamazepine
Phenytoin Phenobarbital Valproate |
|
|
AEDs that may exacerbate absence and myoclonic seizures
|
Phenytoin
Carbamazepine |
|
|
AED that may exacerbate myclonic seizures
|
Lamotrigine
|
|
|
1. Best evidence for monotherapy for absence seizures
2. Also shown to be effective |
1. Ethosuximide
Valproate 2. Lamotrigine |
|
|
Best evidence for myclonic seizures
|
Valproate
Levetiracetam (FDA adjunctive) Clonazepam |
|
|
Monotherapy for Lennox-Gastaut Syndrome
|
Topiramate
Felbamate Clonazepam Lamotrigine Rufinimide (FDA approval is for adjunctive treatment for all except clonazepam) |
|
|
Why AED monotherapy?
|
-Simplifies treatment
-reduces adverse effects -First drug monotherapy fails in about 50% of patients with epilepsy (36% of patients will continue to have seizures regardless of regimen) |
|
|
AEDs that may induce the metabolism of other drugs:
|
Carbamazepine
Phenytoin Phenobarbital Primidone |
|
|
AEDs that cause ED:
|
Primidone
Phenobarbital |
|
|
Clonazepam
|
Klonopin (PO)
-1.5mg -20mg |
|
|
Primidone
|
Mysoline (PO)
-100-125mg -2000mg |
|
|
Rufinamide
|
Banzel (PO)
-200-400 BID (start less <400 if pt is on VPA) -3200 (Lennox-Gastaut) |
|
|
AEDs that are highly protein bound
|
VPA
Phenytoin Tiagibine Carbamazepine Oxcarbazepine (Topiramate is moderately protein bound) |
|
|
Other drugs that may alter metabolism or protein binding of AED
|
Antibiotics
Chemotherapeutic Agents Antidepressants |
|
|
Best evidence and FDA indication to treat tonic-clonic seizures
|
Valproate
Topiramate |
|
|
Monotherapy for partial seizures
1. Best evidence and FDA indication: 2. Similar efficacy, likely better tolerated: |
1. Carbamazepine
Oxcarbazepine Phenytoin Topiramate 2. Lamotrigine Gabapentin Levetiracetam |
