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32 Cards in this Set
- Front
- Back
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The goal of Depot Injections
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The goal is to inject a product that slowlys releases it active component.
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Types of Depot Injectibles?
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SC or IM
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Depot injections for susoensions are formulated how and why?
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They are formulated in water or oil. The drug takes a long time to release or dissolve.
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Depot injections of produgs are usually?
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Lipophillic - Thus slows down the partitioning from (oil) or fat into interstitial fluids.
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How is the active drug release in prodrugs?
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They are hydrolyzed to release the active drug.
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Vaccines are usually bound to a _____________ ___________ ________ that slowly release antigen.
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Vaccines bound to aluminum hydroxide gel that slowly reease antigen
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Bioerodible microsperes act as bioerodible ____ ____ to prolong ________ ________
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Bioerodible microsperes act as bioerodible matrix systems to prolong drug release
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What is an example of a depot that is a bioerodible microsphere?
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Lupron Depot
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The Lupron Depot are prepared as copolymers of ?
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poly (lactic acid) or poly (glycolic acids)---breaks down to lactic and glycolic acids
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The Lupron Depot is available as IM in what duration
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1, 3, 4 controlled release suspension
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Implants are usually given
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Subcutaneous
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What are the two types of implant?
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polymer and mechanical
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T/F Polymer implants which are membraned controlled are usually biodegradleble.
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F
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How are polymer implants which are membraned controlled inserted and removed?
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Surgically
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What release order are membraned controlled polymer implants?
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Zero Ordered
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What are two types of Polymer implants which are membraned controlled?
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Implanon (etonogestrel) and Histrelin acetate implants
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Suprellen LA and Vantas are examples of?
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Polymer implants which are membraned controlled
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Suprellen LA is used for?
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Central Precocious Puberty
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Vantas is used for?
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Palliative treatment of advance prostate cancer
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Describe Implanon (etonogestrel)
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One Implant of etonogestrel crystals imbedded in a solid ethylene vinyl acetate polymer matrix surrounded by rate controlling EVA membrane
Can be used for up to three years for contraception |
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Which bioerodible drug product is made from the same monomers used for Lupron? Where is it inserted?
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Zoladex
SC in the abdomen |
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Describe the Gliadel wafer?
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An intracranial implant of Carmustine homogeneously dispersed in a bioerodible polymer matrix
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What are the different effects of the Gliadel wafer?
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The polymer degrades at the surface, slowly releasing the drug.
-Protects the drug from degradation |
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How is carmustine delivered using Gliadel?
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Carmustine is delivered locally into the surrounding tissue.
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What happens with Eligard?
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Tissue water causes the polymer to precipatate and trap the drug in a solid implant.
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ATRIGEL and Leuprolide acetate
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Eligard
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T/F Mechanical implants uses negative pressure to deliver the medication.
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False - Positive Pressure
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Implantable infusion pumps are self contained units consiting of
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A pumpling mechanism, drug reservoir and cathether
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Implantable infusion pumps are usually implanted where?
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in a subcutaneous pocket (subclavian foss or abdomen)
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How is a drug pumped using a synchromed?
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The drug is pumped from a reservior into a catheter by a peristaltic mechanism
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Drugs approved for used using Syncromed
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morphine, doxorubicin, cisplatin, MTX, and baclofen
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The Mini Med uses a _____ to force fluid out
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Piston so it gentler or insulin
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