Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
|
norepinephrin
|
alfa/beta, shock, heart fail, rarely used.
bad- HT, VasoCon, TachyCar, dys arrit. poorly abs. oraly, plasma T1\2 2min |
|
|
Epinephrin
|
alfa\beta
good- asthma, anaphylactic shock, carrdiac arrest, add to local anaesth. bad- HT, vasoCon, tachiCard, dysArrit. admin.-IV or SC |
|
|
Isoprenaline
|
beta
good- asthma (obsolete) bad-tachiCard, dysAritt. plasma t 1\2- 2h. |
|
|
Dobutamine
|
beta1
good- cardiogenic shock bad- dysrhytmia P t1\2- 2min admin. IV |
|
|
Salbutamol
|
beta2
good- asthma, premature labour. bad- tachiCard. dysrhytm, tremor, peripheral vasoDilation Admin- IV\aerosol |
|
|
Salmeterol
|
beta2
good-asthma bad- tachiCard, dysrytm, tremor, periphreal vasodilation. admin- aerosol, long acting similar to Formoterol |
|
|
Terbutaline
|
beta2
good- astham bad- tachiCard, dysrytm, tremor, peripheral vasodilation. admin- aerosol, t1\2 4h |
|
|
Clenbuterol
|
beta2
good- increase muscle strength. bad- tachiCard, dysrytm, tremor, peripheral vasodilation. admin- orally, long acting |
|
|
Phenylephrine
|
alfa1
good- nasal decongestion bad-HT, reflex bradyCard admin- intranasal, short t 1\2 |
|
|
Methoxamine
|
alfa
good- nasal decongestion bad- HT, reflex bradiCard admin- intranasal, t1\2 1h |
|
|
Clonidine
|
alfa2 partial agonist
good- HT, migraine bad- drowsiness, orthostatic & rebound HypoTens, edema. admin- oral, t1\2 12h |
|
|
Tyramine
|
indirect ago- NA release
same as norepinephrin normally destroyed in gut by MAO. doesn't enter brain. |
|
|
Amphetamine
|
indirect agon- NA release, MAO inhibt.
good- CNS stimulant in ADD, narcolepsy & appetite suppress. bad- HT, TachiCard, insomnia. admin- oral, pass to brain, t1\2 12h. |
|
|
Ephedrine
|
indirect agon- NA release, beta agonist, weak CNS stimulant.
good- nasal decongestion. bad- HT, tachiCard, insomnia (less then amphitamine). admin- oral, pass to brain, t1\2 12h. contraindicated to MAO inhibitors |
|
|
Phenoxybenzamine
|
alfa antagonist (irreversible)
good- phaeochromoctoma bad- HypoT, flushing, tachiCard, nasal congestion, impotence. admin.- oral, t1\2 12h. action outlast presence in plasma. |
|
|
Phentolamine
|
alfa antagonist
vasodilator, rare use bad- HypoT, flushing, tachiCard, nasal cogestion, impotence. admin- IV, metabol- liver, t1\2 2h. Tolazoline is similar |
|
|
Prazosin
|
alfa1 antagonist
good-HT bad- HypoT, flushing, nasal congestion, impotence. admin- oraly, met. by liver, t1\2 4h. similar but longer acting- Doxazolin , Terazosin. |
|
|
Tamsulosin
|
alfa1 antagonist "uroselective"
good- prostatic hyperplasia. bad- fail to ejaculate. oral, t1\2 5h. |
|
|
Propranolol
|
beta antagonist
good- angina, HT, dysrhytmias, anxiety, tremor, glaucoma. bad- bronchoconstriction, heart fail, cold extremities, fatigue & depression, hypoglycemia. oral, first pass met, 90% bound to protein, t1\2 4h Timolol similar (for glaucoma) |
|
|
Alprenolol
|
beta antagonist (partial agonist)
good- angina, HT, dysrrhytmia, anxiety, tremor, glaucoma. bad- bronchoCon, heart fail, cold extremities, fatigue & depression, hypoglycemia. oral, met by liver, t1\2 4h. similar- Oxprenolol, Pindolol. |
|
|
Metoprolol
|
beta1 antagonist
good- angina, HT, dysrhytmias. bad- heart fail, cold extremities, fatigue & depression, hypoglycemia. oral, met by liver, t1\2 3h. Atenolol is similar with longer t1\2. |
|
|
Labetalol
|
alfa\beta antagonist
good- HT in pregnancy. bad- postural hypoTens, bronchoconstriction. oral, conjugated in liver, t1\2 4h |
|
|
Carvedilol
|
alfa\beta antagonist
good- heart fail. bad- exacerbate heart fail, renal fail. oral, t1\2 10h |
|
|
Carbidopa
|
inhibit DOPA decarboxylase.
good- in adjunct to L-DOPA to prevent peripheral effects. oral, doesn't enter brain. |
|
|
Methyldopa
|
false transmitter precursor.
good- HT in pregnancy. bad- hypoTens, drowsiness, diarrhea, impotence, hypersensitivity reaction. slow oral. |
|
|
Reserpine
|
deplete NA stores by inhibit uptake.
good- HT (obsolete). bad- hypoTens, drowsiness, diarrhea, impotence, hypersensitivity reaction, depression, parkinson, gyneacomastia. t1\2 6h, poor oral abs. |
|
|
Guanethidine
|
inhibit NA release.
can damage NA neuron irreversibly. good- HT (obsolete). bad- hypoTens, drowsiness, diarrhea, impotence, hypersensitivity reaction. t1\2 100h |
|
|
Imipramine
|
block uptake (also atropine like effect)
good- depression. bad- atropine like, heart dysrhytmea in overdose. oral,bount to protein, t1\2 4h. similar- Desipramine, Amitriptyline. |
|
|
Cocaine
|
block uptake
good- local anesthetic, CNS stimuli. bad- HT, convulsions, dependence. oral |
